Mutations in RAS/BRAF genes in rectal tumors: From adenomas to early carcinomas
- 作者: Shelygin Y.1, Maynovskaya O.1, Rybakov E.1, Shubin V.1, Chernyshov S.1, Frolov S.1, Kashnikov V.1, Pospekhova N.1
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隶属关系:
- Ryzhikh State Scientific Center of Coloproctology
- 期: 卷 53, 编号 10 (2017)
- 页面: 1146-1151
- 栏目: Human Genetics
- URL: https://journals.rcsi.science/1022-7954/article/view/188492
- DOI: https://doi.org/10.1134/S1022795417080075
- ID: 188492
如何引用文章
详细
The frequency and spectrum of mutations in RAS/BRAF genes were studied in rectal adenomas, carcinomas in situ, and adenocarcinomas. It is shown that the frequency of KRAS mutations decreases from adenoma to adenocarcinoma; most adenomas and carcinomas in situ are heterogeneous and consist of several subclones. Possible models of colorectal cancer pathogenesis are discussed.
作者简介
Yu. Shelygin
Ryzhikh State Scientific Center of Coloproctology
Email: npospekhova@mail.ru
俄罗斯联邦, Moscow, 123423
O. Maynovskaya
Ryzhikh State Scientific Center of Coloproctology
Email: npospekhova@mail.ru
俄罗斯联邦, Moscow, 123423
E. Rybakov
Ryzhikh State Scientific Center of Coloproctology
Email: npospekhova@mail.ru
俄罗斯联邦, Moscow, 123423
V. Shubin
Ryzhikh State Scientific Center of Coloproctology
Email: npospekhova@mail.ru
俄罗斯联邦, Moscow, 123423
S. Chernyshov
Ryzhikh State Scientific Center of Coloproctology
Email: npospekhova@mail.ru
俄罗斯联邦, Moscow, 123423
S. Frolov
Ryzhikh State Scientific Center of Coloproctology
Email: npospekhova@mail.ru
俄罗斯联邦, Moscow, 123423
V. Kashnikov
Ryzhikh State Scientific Center of Coloproctology
Email: npospekhova@mail.ru
俄罗斯联邦, Moscow, 123423
N. Pospekhova
Ryzhikh State Scientific Center of Coloproctology
编辑信件的主要联系方式.
Email: npospekhova@mail.ru
俄罗斯联邦, Moscow, 123423