Mutations in  RAS/BRAF  genes in rectal tumors: From adenomas to early carcinomas

Yu. A. Shelygin; O. A. Maynovskaya; E. G. Rybakov; V. P. Shubin; S. V. Chernyshov; S. A. Frolov; V. N. Kashnikov; N. I. Pospekhova

doi:10.1134/S1022795417080075

Mutations in RAS/BRAF genes in rectal tumors: From adenomas to early carcinomas

Autores: Shelygin Y.¹, Maynovskaya O.¹, Rybakov E.¹, Shubin V.¹, Chernyshov S.¹, Frolov S.¹, Kashnikov V.¹, Pospekhova N.¹
Afiliações:
1. Ryzhikh State Scientific Center of Coloproctology
Edição: Volume 53, Nº 10 (2017)
Páginas: 1146-1151
Seção: Human Genetics
URL: https://journals.rcsi.science/1022-7954/article/view/188492
DOI: https://doi.org/10.1134/S1022795417080075
ID: 188492

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The frequency and spectrum of mutations in RAS/BRAF genes were studied in rectal adenomas, carcinomas in situ, and adenocarcinomas. It is shown that the frequency of KRAS mutations decreases from adenoma to adenocarcinoma; most adenomas and carcinomas in situ are heterogeneous and consist of several subclones. Possible models of colorectal cancer pathogenesis are discussed.