Mutations in  RAS/BRAF  genes in rectal tumors: From adenomas to early carcinomas

Yu. A. Shelygin; O. A. Maynovskaya; E. G. Rybakov; V. P. Shubin; S. V. Chernyshov; S. A. Frolov; V. N. Kashnikov; N. I. Pospekhova

doi:10.1134/S1022795417080075

Mutations in RAS/BRAF genes in rectal tumors: From adenomas to early carcinomas

Authors: Shelygin Y.A.¹, Maynovskaya O.A.¹, Rybakov E.G.¹, Shubin V.P.¹, Chernyshov S.V.¹, Frolov S.A.¹, Kashnikov V.N.¹, Pospekhova N.I.¹
Affiliations:
1. Ryzhikh State Scientific Center of Coloproctology
Issue: Vol 53, No 10 (2017)
Pages: 1146-1151
Section: Human Genetics
URL: https://journals.rcsi.science/1022-7954/article/view/188492
DOI: https://doi.org/10.1134/S1022795417080075
ID: 188492

Cite item

Full Text

Open Access
Restricted Access

Access granted
Restricted Access

Subscription Access

Abstract
About the authors
References
Statistics

Abstract

The frequency and spectrum of mutations in RAS/BRAF genes were studied in rectal adenomas, carcinomas in situ, and adenocarcinomas. It is shown that the frequency of KRAS mutations decreases from adenoma to adenocarcinoma; most adenomas and carcinomas in situ are heterogeneous and consist of several subclones. Possible models of colorectal cancer pathogenesis are discussed.