Enviar artigo por via de e-mail The analysis of association between type 2 diabetes and polymorphic markers in the CDKAL1 gene and in the HHEX/IDE locus
- Autores: Khodyrev D.1, Nikitin A.1, Brovkin A.1, Lavrikova E.1, Lebedeva N.2,3, Vikulova O.2,3, Shamhalova M.2,3, Shestakova M.2,3, Mayorov M.2,3, Potapov V.4, Nosikov V.1, Averyanov A.1
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Afiliações:
- Federal Research Clinical Center of Federal Medical and Biological Agency of Russia
- Department of Pediatrics
- Department of Endocrinology and Diabetology
- Clinic of New Medical Technologies Archimedes
- Edição: Volume 52, Nº 11 (2016)
- Páginas: 1192-1199
- Seção: Human Genetics
- URL: https://journals.rcsi.science/1022-7954/article/view/187996
- DOI: https://doi.org/10.1134/S1022795416110065
- ID: 187996
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Resumo
The increase in diabetes was noted at the turn of the 21st century. Patients with type 2 diabetes (T2DM) make up the majority of patients. Diabetes is a multifactorial disease. It arises from adverse effects of environmental factors on the body of genetically susceptible peoples. According to modern concepts, T2DM is a polygenic disease. Each of the involved genes contributes to the risk of developing of this disease. In our study, the association between polymorphic genetic markers rs7756992, rs9465871, rs7754840, and rs10946398 in the CDKAL1 gene and rs1111875 in the HHEX/IDE locus and T2DM in the Russian population were studied. Four hundred forty patients with type 2 diabetes and 264 healthy individuals without any signs of the disease were examined. The comparative analysis of distribution of genotypes and allele frequencies points to an association between polymorphic genetic markers rs7756992, rs9465871, and rs10946398 in the CDKAL1 gene and this disease. For the other polymorphic genetic markers (rs7754840 in the CDKAL1 gene and rs1111875 in the HHEX/IDE locus), no statistically significant associations are found. On the basis of these data, we can conclude that the CDKAL1 gene is associated with development of T2DM. For the HHEX/IDE locus, such an association is absent.
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Sobre autores
D. Khodyrev
Federal Research Clinical Center of Federal Medical and Biological Agency of Russia
Autor responsável pela correspondência
Email: dmkh008@gmail.com
Rússia, Moscow, 115682
A. Nikitin
Federal Research Clinical Center of Federal Medical and Biological Agency of Russia
Email: dmkh008@gmail.com
Rússia, Moscow, 115682
A. Brovkin
Federal Research Clinical Center of Federal Medical and Biological Agency of Russia
Email: dmkh008@gmail.com
Rússia, Moscow, 115682
E. Lavrikova
Federal Research Clinical Center of Federal Medical and Biological Agency of Russia
Email: dmkh008@gmail.com
Rússia, Moscow, 115682
N. Lebedeva
Department of Pediatrics; Department of Endocrinology and Diabetology
Email: dmkh008@gmail.com
Rússia, Moscow, 117036; Moscow, 119991
O. Vikulova
Department of Pediatrics; Department of Endocrinology and Diabetology
Email: dmkh008@gmail.com
Rússia, Moscow, 117036; Moscow, 119991
M. Shamhalova
Department of Pediatrics; Department of Endocrinology and Diabetology
Email: dmkh008@gmail.com
Rússia, Moscow, 117036; Moscow, 119991
M. Shestakova
Department of Pediatrics; Department of Endocrinology and Diabetology
Email: dmkh008@gmail.com
Rússia, Moscow, 117036; Moscow, 119991
M. Mayorov
Department of Pediatrics; Department of Endocrinology and Diabetology
Email: dmkh008@gmail.com
Rússia, Moscow, 117036; Moscow, 119991
V. Potapov
Clinic of New Medical Technologies Archimedes
Email: dmkh008@gmail.com
Rússia, Moscow, 129128
V. Nosikov
Federal Research Clinical Center of Federal Medical and Biological Agency of Russia
Email: dmkh008@gmail.com
Rússia, Moscow, 115682
A. Averyanov
Federal Research Clinical Center of Federal Medical and Biological Agency of Russia
Email: dmkh008@gmail.com
Rússia, Moscow, 115682
