Email this article The analysis of association between type 2 diabetes and polymorphic markers in the CDKAL1 gene and in the HHEX/IDE locus
- Authors: Khodyrev D.S.1, Nikitin A.G.1, Brovkin A.N.1, Lavrikova E.Y.1, Lebedeva N.O.2,3, Vikulova O.K.2,3, Shamhalova M.S.2,3, Shestakova M.V.2,3, Mayorov M.Y.2,3, Potapov V.A.4, Nosikov V.V.1, Averyanov A.V.1
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Affiliations:
- Federal Research Clinical Center of Federal Medical and Biological Agency of Russia
- Department of Pediatrics
- Department of Endocrinology and Diabetology
- Clinic of New Medical Technologies Archimedes
- Issue: Vol 52, No 11 (2016)
- Pages: 1192-1199
- Section: Human Genetics
- URL: https://journals.rcsi.science/1022-7954/article/view/187996
- DOI: https://doi.org/10.1134/S1022795416110065
- ID: 187996
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Abstract
The increase in diabetes was noted at the turn of the 21st century. Patients with type 2 diabetes (T2DM) make up the majority of patients. Diabetes is a multifactorial disease. It arises from adverse effects of environmental factors on the body of genetically susceptible peoples. According to modern concepts, T2DM is a polygenic disease. Each of the involved genes contributes to the risk of developing of this disease. In our study, the association between polymorphic genetic markers rs7756992, rs9465871, rs7754840, and rs10946398 in the CDKAL1 gene and rs1111875 in the HHEX/IDE locus and T2DM in the Russian population were studied. Four hundred forty patients with type 2 diabetes and 264 healthy individuals without any signs of the disease were examined. The comparative analysis of distribution of genotypes and allele frequencies points to an association between polymorphic genetic markers rs7756992, rs9465871, and rs10946398 in the CDKAL1 gene and this disease. For the other polymorphic genetic markers (rs7754840 in the CDKAL1 gene and rs1111875 in the HHEX/IDE locus), no statistically significant associations are found. On the basis of these data, we can conclude that the CDKAL1 gene is associated with development of T2DM. For the HHEX/IDE locus, such an association is absent.
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About the authors
D. S. Khodyrev
Federal Research Clinical Center of Federal Medical and Biological Agency of Russia
Author for correspondence.
Email: dmkh008@gmail.com
Russian Federation, Moscow, 115682
A. G. Nikitin
Federal Research Clinical Center of Federal Medical and Biological Agency of Russia
Email: dmkh008@gmail.com
Russian Federation, Moscow, 115682
A. N. Brovkin
Federal Research Clinical Center of Federal Medical and Biological Agency of Russia
Email: dmkh008@gmail.com
Russian Federation, Moscow, 115682
E. Yu. Lavrikova
Federal Research Clinical Center of Federal Medical and Biological Agency of Russia
Email: dmkh008@gmail.com
Russian Federation, Moscow, 115682
N. O. Lebedeva
Department of Pediatrics; Department of Endocrinology and Diabetology
Email: dmkh008@gmail.com
Russian Federation, Moscow, 117036; Moscow, 119991
O. K. Vikulova
Department of Pediatrics; Department of Endocrinology and Diabetology
Email: dmkh008@gmail.com
Russian Federation, Moscow, 117036; Moscow, 119991
M. Sh. Shamhalova
Department of Pediatrics; Department of Endocrinology and Diabetology
Email: dmkh008@gmail.com
Russian Federation, Moscow, 117036; Moscow, 119991
M. V. Shestakova
Department of Pediatrics; Department of Endocrinology and Diabetology
Email: dmkh008@gmail.com
Russian Federation, Moscow, 117036; Moscow, 119991
M. Yu. Mayorov
Department of Pediatrics; Department of Endocrinology and Diabetology
Email: dmkh008@gmail.com
Russian Federation, Moscow, 117036; Moscow, 119991
V. A. Potapov
Clinic of New Medical Technologies Archimedes
Email: dmkh008@gmail.com
Russian Federation, Moscow, 129128
V. V. Nosikov
Federal Research Clinical Center of Federal Medical and Biological Agency of Russia
Email: dmkh008@gmail.com
Russian Federation, Moscow, 115682
A. V. Averyanov
Federal Research Clinical Center of Federal Medical and Biological Agency of Russia
Email: dmkh008@gmail.com
Russian Federation, Moscow, 115682
