Genome-wide mapping of copy number variations in commercial hybrid pigs using a high-density SNP genotyping array
- Autores: Zhou L.1, Li J.1, Yang J.1, Liu C.1, Xie X.1, He Y.1, Liu X.1, Xin W.1, Zhang W.1, Ren J.1, Ma J.1, Huang L.1
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Afiliações:
- State Key Laboratory for Pig Genetics and Production Technology
- Edição: Volume 52, Nº 1 (2016)
- Páginas: 85-92
- Seção: Animal Genetics
- URL: https://journals.rcsi.science/1022-7954/article/view/187622
- DOI: https://doi.org/10.1134/S1022795415120145
- ID: 187622
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Resumo
Copy number variations (CNVs) are important forms of structural variation in human and animals and can be considered as a major genetic component of phenotypic diversity. Here we used the Illumina PorcineSNP60 BeadChip V2 and a DLY [Duroc × (Large White × Landrace)] commercial hybrid population to identify 272 CNVs belonging to 165 CNV regions (CNVRs), of which 66 are new. As CNVRs are specific to origin of population, our DLY-specific data is an important complementary to the existing CNV map in the pig genome. Eight CNVRs were selected for validation by quantitative real-time PCR (qRT-PCR) and the accurate rate was high (87.25%). Gene function analysis suggested that a common CNVR may play an important role in multiple traits, including growth rate and carcass quality.
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Sobre autores
L. Zhou
State Key Laboratory for Pig Genetics and Production Technology
Email: ma_junwu@hotmail.com
República Popular da China, Nanchang, 330045
J. Li
State Key Laboratory for Pig Genetics and Production Technology
Email: ma_junwu@hotmail.com
República Popular da China, Nanchang, 330045
J. Yang
State Key Laboratory for Pig Genetics and Production Technology
Email: ma_junwu@hotmail.com
República Popular da China, Nanchang, 330045
C. Liu
State Key Laboratory for Pig Genetics and Production Technology
Email: ma_junwu@hotmail.com
República Popular da China, Nanchang, 330045
X. Xie
State Key Laboratory for Pig Genetics and Production Technology
Email: ma_junwu@hotmail.com
República Popular da China, Nanchang, 330045
Y. He
State Key Laboratory for Pig Genetics and Production Technology
Email: ma_junwu@hotmail.com
República Popular da China, Nanchang, 330045
X. Liu
State Key Laboratory for Pig Genetics and Production Technology
Email: ma_junwu@hotmail.com
República Popular da China, Nanchang, 330045
W. Xin
State Key Laboratory for Pig Genetics and Production Technology
Email: ma_junwu@hotmail.com
República Popular da China, Nanchang, 330045
W. Zhang
State Key Laboratory for Pig Genetics and Production Technology
Email: ma_junwu@hotmail.com
República Popular da China, Nanchang, 330045
J. Ren
State Key Laboratory for Pig Genetics and Production Technology
Email: ma_junwu@hotmail.com
República Popular da China, Nanchang, 330045
J. Ma
State Key Laboratory for Pig Genetics and Production Technology
Autor responsável pela correspondência
Email: ma_junwu@hotmail.com
República Popular da China, Nanchang, 330045
L. Huang
State Key Laboratory for Pig Genetics and Production Technology
Email: ma_junwu@hotmail.com
República Popular da China, Nanchang, 330045