Genetic Aspects of Drug Resistance and Virulence in Mycobacterium tuberculosis
- Authors: Shur K.V.1, Bekker O.B.1, Zaichikova M.V.1, Maslov D.A.1, Akimova N.I.1, Zakharevich N.V.1, Chekalina M.S.1, Danilenko V.N.1
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Affiliations:
- Vavilov Institute of General Genetics Russian Academy of Sciences
- Issue: Vol 54, No 12 (2018)
- Pages: 1385-1396
- Section: Reviews and Theoretical Articles
- URL: https://journals.rcsi.science/1022-7954/article/view/188698
- DOI: https://doi.org/10.1134/S1022795418120141
- ID: 188698
Cite item
Abstract
Drug-resistant Mycobacterium tuberculosis and its high virulence new strains present a global health threat. The solution of this problem requires the development of new anti-tuberculosis drugs. Investigation of the genetic mechanisms associated with the development of multidrug resistant M. tuberculosis strains is the basis for the search for new biotargets of anti-tuberculosis drugs. To date, the molecular genetic relationships between genes controlling drug resistance and virulence remain poorly investigated and require special attention. In the present study, genetic mechanisms of interaction of genetic systems of drug resistance and virulence of M. tuberculosis are considered.
About the authors
K. V. Shur
Vavilov Institute of General Genetics Russian Academy of Sciences
Email: valerid@vigg.ru
Russian Federation, Moscow, 119991
O. B. Bekker
Vavilov Institute of General Genetics Russian Academy of Sciences
Email: valerid@vigg.ru
Russian Federation, Moscow, 119991
M. V. Zaichikova
Vavilov Institute of General Genetics Russian Academy of Sciences
Email: valerid@vigg.ru
Russian Federation, Moscow, 119991
D. A. Maslov
Vavilov Institute of General Genetics Russian Academy of Sciences
Email: valerid@vigg.ru
Russian Federation, Moscow, 119991
N. I. Akimova
Vavilov Institute of General Genetics Russian Academy of Sciences
Email: valerid@vigg.ru
Russian Federation, Moscow, 119991
N. V. Zakharevich
Vavilov Institute of General Genetics Russian Academy of Sciences
Email: valerid@vigg.ru
Russian Federation, Moscow, 119991
M. S. Chekalina
Vavilov Institute of General Genetics Russian Academy of Sciences
Email: valerid@vigg.ru
Russian Federation, Moscow, 119991
V. N. Danilenko
Vavilov Institute of General Genetics Russian Academy of Sciences
Author for correspondence.
Email: valerid@vigg.ru
Russian Federation, Moscow, 119991