Genetic Aspects of Drug Resistance and Virulence in Mycobacterium tuberculosis
- Autores: Shur K.1, Bekker O.1, Zaichikova M.1, Maslov D.1, Akimova N.1, Zakharevich N.1, Chekalina M.1, Danilenko V.1
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Afiliações:
- Vavilov Institute of General Genetics Russian Academy of Sciences
- Edição: Volume 54, Nº 12 (2018)
- Páginas: 1385-1396
- Seção: Reviews and Theoretical Articles
- URL: https://journals.rcsi.science/1022-7954/article/view/188698
- DOI: https://doi.org/10.1134/S1022795418120141
- ID: 188698
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Resumo
Drug-resistant Mycobacterium tuberculosis and its high virulence new strains present a global health threat. The solution of this problem requires the development of new anti-tuberculosis drugs. Investigation of the genetic mechanisms associated with the development of multidrug resistant M. tuberculosis strains is the basis for the search for new biotargets of anti-tuberculosis drugs. To date, the molecular genetic relationships between genes controlling drug resistance and virulence remain poorly investigated and require special attention. In the present study, genetic mechanisms of interaction of genetic systems of drug resistance and virulence of M. tuberculosis are considered.
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Sobre autores
K. Shur
Vavilov Institute of General Genetics Russian Academy of Sciences
Email: valerid@vigg.ru
Rússia, Moscow, 119991
O. Bekker
Vavilov Institute of General Genetics Russian Academy of Sciences
Email: valerid@vigg.ru
Rússia, Moscow, 119991
M. Zaichikova
Vavilov Institute of General Genetics Russian Academy of Sciences
Email: valerid@vigg.ru
Rússia, Moscow, 119991
D. Maslov
Vavilov Institute of General Genetics Russian Academy of Sciences
Email: valerid@vigg.ru
Rússia, Moscow, 119991
N. Akimova
Vavilov Institute of General Genetics Russian Academy of Sciences
Email: valerid@vigg.ru
Rússia, Moscow, 119991
N. Zakharevich
Vavilov Institute of General Genetics Russian Academy of Sciences
Email: valerid@vigg.ru
Rússia, Moscow, 119991
M. Chekalina
Vavilov Institute of General Genetics Russian Academy of Sciences
Email: valerid@vigg.ru
Rússia, Moscow, 119991
V. Danilenko
Vavilov Institute of General Genetics Russian Academy of Sciences
Autor responsável pela correspondência
Email: valerid@vigg.ru
Rússia, Moscow, 119991