Population biobanks: Organizational models and prospects of application in gene geography and personalized medicine
- Authors: Balanovska E.V.1, Zhabagin M.K.2, Agdzhoyan A.T.1,3, Chukhryaeva M.I.1,3, Markina N.V.3, Balaganskaya O.A.3, Skhalyakho R.A.1,3, Yusupov Y.M.4, Utevska O.M.5, Bogunov Y.V.3, Asilguzhin R.R.4, Dolinina D.O.6, Kagazezheva Z.A.7, Damba L.D.8, Zaporozhchenko V.V.1,3, Romanov A.G.1, Dibirova K.D.1,3, Kuznetsova M.A.1, Lavryashina M.B.6, Pocheshkhova E.A.7, Balanovsky O.P.1,3
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Affiliations:
- Research Centre for Medical Genetics
- Nazarbayev University
- Vavilov Institute of General Genetics
- Institute for Strategic Studies of the Republic of Bashkortostan
- Department of Genetics and Cytology
- Department of Genetics
- Department of Biology
- Institute of Medical and Social Problems
- Issue: Vol 52, No 12 (2016)
- Pages: 1227-1243
- Section: Reviews and Theoretical Articles
- URL: https://journals.rcsi.science/1022-7954/article/view/188017
- DOI: https://doi.org/10.1134/S1022795416120024
- ID: 188017
Cite item
Abstract
Population biobanks are collections of thoroughly annotated biological material stored for many years. Population biobanks are a valuable resource for both basic science and applied research and are essential for extensive analysis of gene pools. Population biobanks make it possible to carry out fundamental studies of the genetic structure of populations, explore their genetic processes, and reconstruct their genetic history. The importance of biobanks for applied research is no less significant: they are essential for development of personalized medicine and genetic ecological monitoring of populations and are in high demand in forensic science. Establishment of an efficient and representative biobank requires strict observance of the principles of sample selection in populations, protocols of DNA extraction, quality control, and storage and documentation of biological materials. We reviewed regional biobanks and presented the organizational model of population biobank establishment based on the Biobank of Indigenous Population of Northern Eurasia created under supervision of E.V. Balanovska and O.P. Balanovsky. The results obtained using the biobanks in transdisciplinary research and prospective applications for the purposes of genogeography, genomic medicine, and forensic science are presented.
About the authors
E. V. Balanovska
Research Centre for Medical Genetics
Email: balanovsky@inbox.ru
Russian Federation, Moscow, 115478
M. K. Zhabagin
Nazarbayev University
Email: balanovsky@inbox.ru
Kazakhstan, Astana, 010017
A. T. Agdzhoyan
Research Centre for Medical Genetics; Vavilov Institute of General Genetics
Email: balanovsky@inbox.ru
Russian Federation, Moscow, 115478; Moscow, 119991
M. I. Chukhryaeva
Research Centre for Medical Genetics; Vavilov Institute of General Genetics
Email: balanovsky@inbox.ru
Russian Federation, Moscow, 115478; Moscow, 119991
N. V. Markina
Vavilov Institute of General Genetics
Email: balanovsky@inbox.ru
Russian Federation, Moscow, 119991
O. A. Balaganskaya
Vavilov Institute of General Genetics
Email: balanovsky@inbox.ru
Russian Federation, Moscow, 119991
R. A. Skhalyakho
Research Centre for Medical Genetics; Vavilov Institute of General Genetics
Email: balanovsky@inbox.ru
Russian Federation, Moscow, 115478; Moscow, 119991
Yu. M. Yusupov
Institute for Strategic Studies of the Republic of Bashkortostan
Email: balanovsky@inbox.ru
Russian Federation, Ufa, 450000
O. M. Utevska
Department of Genetics and Cytology
Email: balanovsky@inbox.ru
Ukraine, Kharkiv, 61022
Yu. V. Bogunov
Vavilov Institute of General Genetics
Email: balanovsky@inbox.ru
Russian Federation, Moscow, 119991
R. R. Asilguzhin
Institute for Strategic Studies of the Republic of Bashkortostan
Email: balanovsky@inbox.ru
Russian Federation, Ufa, 450000
D. O. Dolinina
Department of Genetics
Email: balanovsky@inbox.ru
Russian Federation, Kemerovo, 650043
Zh. A. Kagazezheva
Department of Biology
Email: balanovsky@inbox.ru
Russian Federation, Krasnodar, 350063
L. D. Damba
Institute of Medical and Social Problems
Email: balanovsky@inbox.ru
Russian Federation, Kyzyl, Tyva Republic, 667000
V. V. Zaporozhchenko
Research Centre for Medical Genetics; Vavilov Institute of General Genetics
Email: balanovsky@inbox.ru
Russian Federation, Moscow, 115478; Moscow, 119991
A. G. Romanov
Research Centre for Medical Genetics
Email: balanovsky@inbox.ru
Russian Federation, Moscow, 115478
Kh. D. Dibirova
Research Centre for Medical Genetics; Vavilov Institute of General Genetics
Email: balanovsky@inbox.ru
Russian Federation, Moscow, 115478; Moscow, 119991
M. A. Kuznetsova
Research Centre for Medical Genetics
Email: balanovsky@inbox.ru
Russian Federation, Moscow, 115478
M. B. Lavryashina
Department of Genetics
Email: balanovsky@inbox.ru
Russian Federation, Kemerovo, 650043
E. A. Pocheshkhova
Department of Biology
Email: balanovsky@inbox.ru
Russian Federation, Krasnodar, 350063
O. P. Balanovsky
Research Centre for Medical Genetics; Vavilov Institute of General Genetics
Author for correspondence.
Email: balanovsky@inbox.ru
Russian Federation, Moscow, 115478; Moscow, 119991