Population biobanks: Organizational models and prospects of application in gene geography and personalized medicine

E. V. Balanovska; M. K. Zhabagin; A. T. Agdzhoyan; M. I. Chukhryaeva; N. V. Markina; O. A. Balaganskaya; R. A. Skhalyakho; Yu. M. Yusupov; O. M. Utevska; Yu. V. Bogunov; R. R. Asilguzhin; D. O. Dolinina; Zh. A. Kagazezheva; L. D. Damba; V. V. Zaporozhchenko; A. G. Romanov; Kh. D. Dibirova; M. A. Kuznetsova; M. B. Lavryashina; E. A. Pocheshkhova; O. P. Balanovsky

doi:10.1134/S1022795416120024

Population biobanks: Organizational models and prospects of application in gene geography and personalized medicine

Авторлар: Balanovska E.¹, Zhabagin M.², Agdzhoyan A.¹^,3, Chukhryaeva M.¹^,3, Markina N.³, Balaganskaya O.³, Skhalyakho R.¹^,3, Yusupov Y.⁴, Utevska O.⁵, Bogunov Y.³, Asilguzhin R.⁴, Dolinina D.⁶, Kagazezheva Z.⁷, Damba L.⁸, Zaporozhchenko V.¹^,3, Romanov A.¹, Dibirova K.¹^,3, Kuznetsova M.¹, Lavryashina M.⁶, Pocheshkhova E.⁷, Balanovsky O.¹^,3
Мекемелер:
1. Research Centre for Medical Genetics
2. Nazarbayev University
3. Vavilov Institute of General Genetics
4. Institute for Strategic Studies of the Republic of Bashkortostan
5. Department of Genetics and Cytology
6. Department of Genetics
7. Department of Biology
8. Institute of Medical and Social Problems
Шығарылым: Том 52, № 12 (2016)
Беттер: 1227-1243
Бөлім: Reviews and Theoretical Articles
URL: https://journals.rcsi.science/1022-7954/article/view/188017
DOI: https://doi.org/10.1134/S1022795416120024
ID: 188017

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Аннотация

Population biobanks are collections of thoroughly annotated biological material stored for many years. Population biobanks are a valuable resource for both basic science and applied research and are essential for extensive analysis of gene pools. Population biobanks make it possible to carry out fundamental studies of the genetic structure of populations, explore their genetic processes, and reconstruct their genetic history. The importance of biobanks for applied research is no less significant: they are essential for development of personalized medicine and genetic ecological monitoring of populations and are in high demand in forensic science. Establishment of an efficient and representative biobank requires strict observance of the principles of sample selection in populations, protocols of DNA extraction, quality control, and storage and documentation of biological materials. We reviewed regional biobanks and presented the organizational model of population biobank establishment based on the Biobank of Indigenous Population of Northern Eurasia created under supervision of E.V. Balanovska and O.P. Balanovsky. The results obtained using the biobanks in transdisciplinary research and prospective applications for the purposes of genogeography, genomic medicine, and forensic science are presented.

Негізгі сөздер

biobank, population, Northern Eurasia, genogeography, gene pool, personalized medicine, forensic expertise, DNA identification, monitoring

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Population biobanks: Organizational models and prospects of application in gene geography and personalized medicine

Толық мәтін

Аннотация

Негізгі сөздер

Авторлар туралы

E. Balanovska

M. Zhabagin

A. Agdzhoyan

M. Chukhryaeva

N. Markina

O. Balaganskaya

R. Skhalyakho

Yu. Yusupov

O. Utevska

Yu. Bogunov

R. Asilguzhin

D. Dolinina

Zh. Kagazezheva

L. Damba

V. Zaporozhchenko

A. Romanov

Kh. Dibirova

M. Kuznetsova

M. Lavryashina

E. Pocheshkhova

O. Balanovsky

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