Email this article Genetic control of circadian rhythms and aging
- Authors: Solovyov I.A.1,2, Dobrovol’skaya E.V.1, Moskalev A.A.1,2,3,4
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Affiliations:
- Institute of Biology, Komi Research Center, Ural Branch
- Department of Biology
- Moscow Institute of Physics and Technology
- Vavilov Institute of General Genetics
- Issue: Vol 52, No 4 (2016)
- Pages: 343-361
- Section: Reviews and Theoretical Articles
- URL: https://journals.rcsi.science/1022-7954/article/view/187672
- DOI: https://doi.org/10.1134/S1022795416040104
- ID: 187672
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Abstract
The review establishes a link between a group of genes which are conserved in evolution and form a molecular oscillator responsible for generation of circadian rhythms and genetic determinants of aging including associated pathways of intracellular signaling. An analysis of mechanisms of development of agedependent pathologies is conducted from the viewpoint of circadian genetics. Systematic data of circadian gene expression studies in animals demonstrating different rates of aging from accelerated to negligible are presented.
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About the authors
I. A. Solovyov
Institute of Biology, Komi Research Center, Ural Branch; Department of Biology
Author for correspondence.
Email: amoskalev@ib.komisc.ru
Russian Federation, Syktyvkar, 167000; Syktyvkar, 167001
E. V. Dobrovol’skaya
Institute of Biology, Komi Research Center, Ural Branch
Email: amoskalev@ib.komisc.ru
Russian Federation, Syktyvkar, 167000
A. A. Moskalev
Institute of Biology, Komi Research Center, Ural Branch; Department of Biology; Moscow Institute of Physics and Technology; Vavilov Institute of General Genetics
Email: amoskalev@ib.komisc.ru
Russian Federation, Syktyvkar, 167000; Syktyvkar, 167001; Dolgoprudny, Moscow region, 141707; Moscow, 119991
