The Role of Dopamine in Chronic Pain: Neuroinflammation and Neurogenesis

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Abstract

Chronic pain is a complex condition that directly affects the quality of life of patients. Regulation and treatment of chronic pain are associated with a number of difficulties, primarily due to the multifactorial nature of this condition. The causes of chronic pain can be associated not only with physical damage, such as various injuries, diseases and the development of neuroinflammation, but also with a violation of the synthesis of neurotransmitters, as well as complex processes of neurogenesis. In this review, we describe the complex and multifaceted interaction between dopaminergic regulation, neurogenesis and neuroinflammation on the development of chronic pain. Further studies of these relationships can lead to the creation of targeted therapeutic strategies aimed at eliminating chronic pain. Moreover, understanding the mechanisms underlying analgesia associated with the dopamine reward system can form the basis for the development of new therapeutic approaches to relieve and control pain.

About the authors

A. Vetlugina

Department of Neurobiology, Scientific Center of Genetics and Life Sciences, Sirius University of Science and Technology

Federal Territory of Sirius, Russia

N. O. Fokeeva

Department of Neurobiology, Scientific Center of Genetics and Life Sciences, Sirius University of Science and Technology

Federal Territory of Sirius, Russia

A. A. Kochneva

Department of Neurobiology, Scientific Center of Genetics and Life Sciences, Sirius University of Science and Technology

Federal Territory of Sirius, Russia

A. V. Kalueff

Department of Neurobiology, Scientific Center of Genetics and Life Sciences, Sirius University of Science and Technology; Institute of Translational Biomedicine, Saint Petersburg State University

Federal Territory of Sirius, Russia; St. Petersburg, Russia

P. E. Musienko

Department of Neurobiology, Scientific Center of Genetics and Life Sciences, Sirius University of Science and Technology; Life Improvement by Future Technologies Center “LIFT”; Federal Center of Brain Research and Neurotechnologies

Federal Territory of Sirius, Russia; Moscow, Russia; Moscow, Russia

E. V. Gerasimova

Department of Neurobiology, Scientific Center of Genetics and Life Sciences, Sirius University of Science and Technology

Email: gerasimova.el.2011@yandex.ru
Federal Territory of Sirius, Russia

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