Event-related desynchronization of eeg sensorimotor rhythms in hemiparesis post-stroke patients

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Motor impairment is one of the most prevalent consequences of a stroke, necessitating the implementation of efficacious diagnostic and rehabilitative techniques. An evaluation of alterations in sensorimotor cortical activity during the processes of movement preparation and execution can provide valuable insights into the state of motor circuits following a stroke and the potential for recovery. The objective of the present study was to evaluate the spatiotemporal characteristics of event-related desynchronization (ERD) of sensorimotor EEG rhythms in patients with hemiparesis following a stroke, during movements with the paretic and healthy hands. A total of 19 patients with hemiparesis following a stroke participated in the study. An EEG was recorded while the subject performed a visual-motor task. The analysis focused on the event-related desynchronization in the alpha (6–15 Hz) and beta (15–30 Hz) bands. An asymmetry in the ERD was observed, with a predominant response in the intact hemisphere, regardless of the hand performing the movement. The magnitude of the ERD in the affected hemisphere demonstrated a correlation with the Fugl-Meyer score. Furthermore, a notable correlation was identified between the magnitude of beta-ERD in the affected hemisphere during movements of the healthy limb and the degree of motor function recovery. The results demonstrate the utility of ERD pattern assessment for diagnosing the state of sensorimotor networks after stroke. The detection of a correlation between the magnitude of ERD during movements of the healthy arm and the assessment of sensorimotor functions of the patient expands the possibilities of using EEG to assess patients even with complete absence of movements in the paretic limb.

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作者简介

А. Medvedeva

Vladimir Zelman Center for Neurobiology and Brain Rehabilitation, Skolkovo Institute of Science and Technology

Email: kolascoco@gmail.com
俄罗斯联邦, Moscow

N. Syrov

Vladimir Zelman Center for Neurobiology and Brain Rehabilitation, Skolkovo Institute of Science and Technology; Lomonosov Moscow State University

编辑信件的主要联系方式.
Email: kolascoco@gmail.com
俄罗斯联邦, Moscow; Moscow

L. Yakovlev

Vladimir Zelman Center for Neurobiology and Brain Rehabilitation, Skolkovo Institute of Science and Technology; Lomonosov Moscow State University

Email: kolascoco@gmail.com
俄罗斯联邦, Moscow; Moscow

Y. Alieva

Federal Center of Brain Research and Neurotechnologies of the federal medical biological agency; Pirogov Russian National Research Medical University

Email: kolascoco@gmail.com
俄罗斯联邦, Moscow; Moscow

D. Petrova

Vladimir Zelman Center for Neurobiology and Brain Rehabilitation, Skolkovo Institute of Science and Technology

Email: kolascoco@gmail.com
俄罗斯联邦, Moscow

G. Ivanova

Federal Center of Brain Research and Neurotechnologies of the federal medical biological agency; Pirogov Russian National Research Medical University

Email: kolascoco@gmail.com
俄罗斯联邦, Moscow; Moscow

М. Lebedev

Lomonosov Moscow State University; Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences

Email: kolascoco@gmail.com
俄罗斯联邦, Moscow; Saint-Petersburg

А. Kaplan

Vladimir Zelman Center for Neurobiology and Brain Rehabilitation, Skolkovo Institute of Science and Technology; Lomonosov Moscow State University

Email: kolascoco@gmail.com
俄罗斯联邦, Moscow; Moscow

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2. Fig. 1. Experimental session diagram. Rectangles represent individual blocks. “R” – blocks with right hand movements, “L” – blocks with left hand movements. Each block included the presentation of 30 visual stimuli, 15 for each button. The subject pressed only the target button in response to the flash of the corresponding light bulb. The appearance of the box with buttons and lights is shown.

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3. Fig. 2. Dynamics of ERD/S in two groups of patients (LH stroke – a group of patients with left-hemisphere stroke; RH stroke – right-hemisphere stroke). (a) – ERD/S dynamics in leads C3 and C4 during movements of the right and left hands. The dynamics are presented in frequency-time coordinates. The diagrams for the conditions of movement of the affected limb are highlighted with a dark frame. (b) – averaged ERD/S values ​​in the alpha and beta ranges are presented separately for blocks with movements of the healthy and affected limbs. The graphs for ERD in leads above the affected hemisphere (C3 for the LH group and C4 for RH) are highlighted with a frame.

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4. Fig. 3. Maps of the topographic distribution of alpha and beta-ERD and beta-ERS reactions for two groups of patients (LH stroke is a group of patients with left-hemisphere stroke, RH stroke is a group with right-hemisphere stroke). Maps are shown for blocks with movements of the healthy and paretic limbs. Darker values ​​on the map reflect higher values ​​of the reaction under study (more negative for ERD, more positive for ERS).

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5. Fig. 4. Group dynamics of ERD/S reactions during movements of the healthy and paretic limbs in two groups of patients – with damage in the left (a) and right hemisphere (b). The values ​​for the leads above the damaged hemisphere are framed (C3 for the group with damage localized in the left hemisphere, and C4 for the group with damage in the right).

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6. Fig. 5. (a) – assessment of the power of rhythmic activity in the alpha and beta ranges in two groups of patients in the leads above the affected and intact hemispheres. “LHS” – data for patients from the group with left-sided stroke, “RHS” – for patients from the group with right-sided stroke. (b) – graphs of the dependence of the alpha/beta value – ERD in the lead above the affected hemisphere and the assessment of sensorimotor skills according to the Fugl-Meyer scale. For the first two diagrams, the ERD values ​​are taken for blocks with movement of the paretic limb, for the rightmost “beta-ERD-ipsi” diagram, the values ​​are taken from the block with movement of the healthy arm.

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7. Appendix 1. Distribution of reaction speed for groups of patients and participants in the control group when moving the right and left hands.

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8. Appendix 2. Results of the analysis of the desynchronization reaction in the control group of healthy volunteers. (a) – frequency-time diagrams of the desynchronization reaction associated with the movement of the right and left hands for participants in the control group. (b) – spatial distribution of alpha and beta desynchronization patterns during movements of the right and left hands for participants in the control group.

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9. Application
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