Analysis of Relaxation Phase in the Rat Heart

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Resumo

The rate and depth of myocardial relaxation determine left ventricular (LV) filling in early diastole. To analyze the relaxation phase, the method of logarithm of LV pressure fall in rats was used. A gradual acceleration of relaxation was found during the transition from the isovolumic phase to the auxovolumic phase, immediately before the opening of the atrioventricular valves. The relaxation rate constant in this phase has been inversely correlated with the values of the minimum LV diastolic pressure and LV endsystolic volume. The results suggest that the gradual acceleration of relaxation is due to the straightening of the spring-like structure of connectin (titin), which is compressed during contraction.

Sobre autores

V. Kapelko

National Medical Research Center of Cardiology, Ministry of Healthcare, Russian Federation

Email: v.lakomkin@yandex.ru
Russia, Moscow

A. Abramov

National Medical Research Center of Cardiology, Ministry of Healthcare, Russian Federation

Email: v.lakomkin@yandex.ru
Russia, Moscow

V. Lakomkin

National Medical Research Center of Cardiology, Ministry of Healthcare, Russian Federation

Autor responsável pela correspondência
Email: v.lakomkin@yandex.ru
Russia, Moscow

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Declaração de direitos autorais © В.И. Капелько, А.А. Абрамов, В.Л. Лакомкин, 2023

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