Mechanisms of Physiological Angiogenesis

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Angiogenesis is the formation of blood vessels from existing vasculature to provide n-ormal tissue perfusion. Angiogenesis is also necessary for the processes of growth and regeneration. Angiogenesis attracts the attention of researchers from the position of its therapeutic regulation: enhancement can contribute to significant progress in the treatment of ischemic diseases, and inhibition is actively studied for the treatment of neoplastic diseases. Regulation of angiogenesis is impossible without accurate knowledge of its mechanism. There are two fundamental pathways for angiogenesis: sprouting angiogenesis, which is mediated by an existing vessel’s endothelial cells migration into the extracellular matrix to form a vessel in the direction of angiogenic stimuli, and intussusceptive angiogenesis, which is mediated by dividing the formed vessel into two new ones as a re-sult of the formation of a partition inside it that separates two independent lumens. This review examines the main stages of each type of physiological angiogenesis, their mechanisms and regulation.

Sobre autores

A. Ivanov

Razumovsky Saratov State Medical University

Email: chabbarov@bk.ru
Russia, Saratov

Yu. Chabbarov

Razumovsky Saratov State Medical University

Autor responsável pela correspondência
Email: chabbarov@bk.ru
Russia, Saratov

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