Neurobiological Effects of Combined Exposure to Antiorthostatic Suspension, Quasi-Chronic Gamma Irradiation and Heavy Ion Irradiation in Rats

Мұқаба

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Тек жазылушылар үшін

Аннотация

We have researched neurobiological effects of physical impacts, modeling conditions of interplanetary space flight: microgravity (modeled by AntiOrthostatic Suspension, AOS) and deep space radiation (modeled by quasi-chronic gamma irradiation and head irradiation by 12C ions) taking into account typological characteristics of high nervous activity (HNA) of model animals (Long Evans male rats). Behavioral changes, as well as EEG and neurochemical changes in key brain areas are investigated. We have shown difference between control and exposed animals, as well as between animals of different HNA typologies (more or less excitable), in motoric and research activity aside as in cognitive abilities. Such difference is driven by shift in balance in main inhibition and exctitation-related neurotransmitters, GABA and GLU and dopaminergic system. In particular, more excitable rats learn faster but are more vulnerable to mentioned model impacts. As a clear sign of HNA distortion we also found some changes in EEG waves.

Авторлар туралы

A. Perevezentsev

Institute of BioMedical Problems of Russian Academy of Sciences

Email: andrei_shtemberg@mail.ru
Russia, Moscow

K. Lebedeva-Georgievskaya

Institute of BioMedical Problems of Russian Academy of Sciences

Email: andrei_shtemberg@mail.ru
Russia, Moscow

O. Kuznetsova

Institute of BioMedical Problems of Russian Academy of Sciences

Email: andrei_shtemberg@mail.ru
Russia, Moscow

V. Kudrin

Institute of BioMedical Problems of Russian Academy of Sciences; Zakusov Institute of Pharmacology of Russian Academy of Medical Sciences

Email: andrei_shtemberg@mail.ru
Russia, Moscow; Russia, Moscow

V. Pikalov

Logunov Institute for High Energy Physics of NRC KI

Email: andrei_shtemberg@mail.ru
Russia, Protvino

A. Shtemberg

Institute of BioMedical Problems of Russian Academy of Sciences

Хат алмасуға жауапты Автор.
Email: andrei_shtemberg@mail.ru
Russia, Moscow

Әдебиет тізімі

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© А.А. Перевезенцев, К.Б. Лебедева-Георгиевская, О.С. Кузнецова, В.С. Кудрин, В.А. Пикалов, А.С. Штемберг, 2023

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