Ожирение и старение. Общие аспекты
- Авторы: Дылева Ю.А.1, Белик Е.В.1, Груздева О.В.1
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Учреждения:
- Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний
- Выпуск: Том 109, № 3 (2023)
- Страницы: 267-282
- Раздел: ОБЗОРНЫЕ И ПРОБЛЕМНЫЕ СТАТЬИ
- URL: https://journals.rcsi.science/0869-8139/article/view/137899
- DOI: https://doi.org/10.31857/S0869813923030020
- EDN: https://elibrary.ru/FSFIKC
- ID: 137899
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Аннотация
Ожирение связано с повышенным риском развития острых и хронических заболеваний, включая гипертонию, инсульт, инфаркт миокарда, сердечно-сосудистые заболевания, диабет, рак, и сокращает продолжительность жизни на срок до 20 лет, увеличивая риск преждевременной смерти. Показано, что метаболические изменения, связанные с ожирением, аналогичны наблюдаемым при старении. Так, ожирение и старение имеют сходный спектр фенотипов, таких как нарушение целостности генома, функции митохондрий, накопление внутриклеточных макромолекул, ослабление иммунитета, системное воспаление. Общность механизмов может лежать в основе ускорения процессов старения как на молекулярном, так и системном уровнях. Таким образом, понимание механизмов дисфункции жировой ткани при ожирении может дать представление о процессах, которые способствуют метаболической дисфункции, связанной с процессом старения. В данном обзоре будут рассмотрены молекулярные и клеточные механизмы, лежащие в основе ожирения и старения, а также как ожирение способно активировать процессы старения, инициируя раннее начало хронических заболеваний, ассоциированных со старением.
Ключевые слова
Об авторах
Ю. А. Дылева
Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний
Автор, ответственный за переписку.
Email: dyleva87@yandex.ru
Россия, Кемерово
Е. В. Белик
Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний
Email: dyleva87@yandex.ru
Россия, Кемерово
О. В. Груздева
Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний
Email: dyleva87@yandex.ru
Россия, Кемерово
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