The Involvement of Acetylcholine and Na+,K+-ATPase in the Regulation of Skeletal Muscle Growth

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Recently, more and more attention has been paid to the discussion of the trophic function of the nervous system and its participation in the launch of signaling cascades regulating cellular metabolism. The role of acetylcholine and Na+,K+-ATPase in the regulation of skeletal muscle growth in 10–12-day-old chicken embryos under conditions of organotypic tissue culture was evaluated. The maximum trophotropic effect of acetylcholine was shown in a concentration 10–8 M. Inhibitory analysis proved the participation of the nicotinic acetylcholine receptor in this effect. Ouabain dose-dependent regulated the growth of skeletal muscle tissue explants. In concentrations comparable to endogenous ones, the glycoside stimulated the growth of experimental explants by 33% compared to the control value. The myotoxic properties of ouabain were found in the concentration range 10–6–10–4 M. Acetylcholine eliminated the myotoxic effect of the ouabain (10–6 M) both directly acting on the Na+,K+-ATPase, and the receptor-mediated through the nicotinic acetylcholine receptor.

作者简介

E. Lopatina

Pavlov First St. Petersburg State Medical University; Pavlov Institute of Physiology Russian Academy of Sciences

编辑信件的主要联系方式.
Email: evlopatina@yandex.ru
Russia, St. Petersburg; Russia, St. Petersburg

A. Gavrichenko

Pavlov First St. Petersburg State Medical University

Email: evlopatina@yandex.ru
Russia, St. Petersburg

N. Pasatetckaia

Pavlov First St. Petersburg State Medical University

Email: evlopatina@yandex.ru
Russia, St. Petersburg

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版权所有 © Е.В. Лопатина, А.В. Гавриченко, Н.А. Пасатецкая, 2023

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