External-beam neutron therapy: the first domestic medical unit

Yu. S. Mardynsky; Мардынский Юрий Станиславович; I. A. Gulidov; Гулидов Игорь Александрович; K. B. Gordon; Гордон Константин Борисович; S. N. Кoryakin; Корякин Сергей Николаевич; А. N. Solovyov; Соловьёв Алексей Николаевич; V. О. Saburov; Сабуров Вячеслав Олегович; S. A. Ivanov; Иванов Сергей Анатольевич; А. D. Kaprin; Каприн Андрей Дмитриевич; Т. K. Lobzhanidze; Лобжанидзе Тенгиз Константинович; N. V. Маrkov; Марков Николай Владимирович; I. М. Zheleznov; Железнов Илья Михайлович; D. I. Yurkov; Юрков Дмитрий Игоревич; О. A. Gerasimchuk; Герасимчук Олег Анатольевич; А. Y. Presnyakov; Пресняков Алексей Юрьевич; V. I. Zverev; Зверев Владимир Игоревич; V. P. Smirnov; Смирнов Валентин Пантелеймонович

doi:10.31857/S0869587324010098

External-beam neutron therapy: the first domestic medical unit

Authors: Mardynsky Y.S.¹, Gulidov I.A.¹, Gordon K.B.¹^,2, Кoryakin S.N.¹^,3, Solovyov А.N.¹^,3, Saburov V.О.¹, Ivanov S.A.¹^,2, Kaprin А.D.²^,4, Lobzhanidze Т.K.⁵, Маrkov N.V.⁵, Zheleznov I.М.⁶, Yurkov D.I.⁶^,7, Gerasimchuk О.A.⁶^,7, Presnyakov А.Y.⁶, Zverev V.I.⁶^,7, Smirnov V.P.⁵
Affiliations:
1. A. Tsyb Medical Radiological Research Center, Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation
2. Lumumba Peoples’ Friendship University of Russia
3. Obninsk Institute of nuclear energy энергетики – branch of the National Research Nuclear University “MEPHI”
4. National Medical Research Radiological Center of the Ministry of Health of the Russian Federation
5. Research Institute of technical physics and automatization
6. Dukhov Automatics Research Institute (VNIIA)
7. National Research Nuclear University “MEPHI”
Issue: Vol 94, No 1 (2024)
Pages: 80-86
Section: ИЗ РАБОЧЕЙ ТЕТРАДИ ИССЛЕДОВАТЕЛЯ
URL: https://journals.rcsi.science/0869-5873/article/view/258769
DOI: https://doi.org/10.31857/S0869587324010098
EDN: https://elibrary.ru/HAHKYZ
ID: 258769

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Abstract

Modern radiotherapy, employing traditional linear accelerators, has nearly reached its apex in terms of efficacy in treating oncological diseases. The challenge before researchers in the field of implementing cutting-edge technologies pertains to the utilization of fundamentally different therapeutic approaches, one of which is remote neutron therapy. Its salient advantages include an increased relative biological effectiveness of radiation, while the complexities of implementing specific technological solutions encompass forming a beam of the required geometry and spectral characteristics.

The article delineates the key milestones in the development of the usage of fast neutron beams for remote radiotherapy, a general description of the neutron therapy complex and its primary structural components is also presented. These are currently being developed as an innovative, mass-producible medical project.

Keywords

radiotherapy, relative biological efficacy, fast neutron therapy, fast neutron therapy unit, radiotherapy planning

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About the authors

Yu. S. Mardynsky

A. Tsyb Medical Radiological Research Center, Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation

Author for correspondence.
Email: mardynsky@mrrc.obninsk.ru

член-корреспондент РАН, главный научный сотрудник МРНЦ им. А.Ф. Цыба

Russian Federation, Obninsk

I. A. Gulidov

A. Tsyb Medical Radiological Research Center, Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation

Email: agulidov@mrrc.obninsk.ru

доктор медицинских наук, заведующий отделом лучевой терапии МРНЦ им. А.Ф. Цыба

Russian Federation, Obninsk

K. B. Gordon

A. Tsyb Medical Radiological Research Center, Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation; Lumumba Peoples’ Friendship University of Russia

Email: gordon@mrrc.obninsk.ru

кандидат медицинских наук, старший научный сотрудник МРНЦ им. А.Ф. Цыба

Russian Federation, Obninsk; Moscow

S. N. Кoryakin

A. Tsyb Medical Radiological Research Center, Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation; Obninsk Institute of nuclear energy энергетики – branch of the National Research Nuclear University “MEPHI”

Email: korsernic@mail.ru

кандидат биологических наук, заведующий отделом радиационной биофизики МРНЦ им. А.Ф. Цыба

Russian Federation, Obninsk; Obninsk

А. N. Solovyov

Email: salonf@mrrc.obninsk.ru

кандидат физико-математических наук, заведующий лабораторией медицинской радиационной физики МРНЦ им. А.Ф. Цыба

Russian Federation, Obninsk; Obninsk

V. О. Saburov

A. Tsyb Medical Radiological Research Center, Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation

Email: vosaburov@gmail.com

инженер МРНЦ им. А.Ф. Цыба

Russian Federation, Obninsk

S. A. Ivanov

Email: oncourolog@gmail.com

член-корреспондент РАН, директор МРНЦ им. А.Ф. Цыба

Russian Federation, Obninsk; Moscow

А. D. Kaprin

Lumumba Peoples’ Friendship University of Russia; National Medical Research Radiological Center of the Ministry of Health of the Russian Federation

Email: kaprin@mail.ru

академик РАН, генеральный директор НМИЦ радиологии Минздрава России

Russian Federation, Moscow; Moscow

Т. K. Lobzhanidze

Research Institute of technical physics and automatization

Email: tklobzhanidze@gmail.com

кандидат физико-математических наук, старший научный сотрудник НИИТФА

Russian Federation, Moscow

N. V. Маrkov

Research Institute of technical physics and automatization

Email: nick.v.markov@gmail.com

доктор технических наук, генеральный директор НИИТФА

Russian Federation, Moscow

I. М. Zheleznov

Dukhov Automatics Research Institute (VNIIA)

Email: zheleznov@vniia.ru

доктор технических наук, заместитель директора ВНИИА

Russian Federation, Moscow

D. I. Yurkov

Dukhov Automatics Research Institute (VNIIA); National Research Nuclear University “MEPHI”

Email: dmitry_yurkov@mail.ru

кандидат технических наук, заведующий кафедрой прикладной ядерной физики НИЯУ МИФИ

Russian Federation, Moscow; Moscow

О. A. Gerasimchuk

Dukhov Automatics Research Institute (VNIIA); National Research Nuclear University “MEPHI”

Email: oleg.gerasimchuk@bk.ru

кандидат технических наук, доцент кафедры прикладной ядерной физики НИЯУ МИФИ

Russian Federation, Moscow; Moscow

А. Y. Presnyakov

Dukhov Automatics Research Institute (VNIIA)

Email: presnyakov_aleks@mail.ru

заместитель начальника отделения ВНИИА

Russian Federation, Moscow

V. I. Zverev

Dukhov Automatics Research Institute (VNIIA); National Research Nuclear University “MEPHI”

Email: vi.zverev@physics.msu.ru

доктор физико-математических наук, физик ВНИИА

Russian Federation, Moscow; Moscow

V. P. Smirnov

Research Institute of technical physics and automatization

Email: valepansmirnov@rosatom.ru

академик РАН, научный руководитель НИИТФА

Russian Federation, Moscow

References

Stone R.S., Lawrence J.H., Aebersold P.C. A Preliminary report on the Use of Fast Neutrons in the Treatment of Malignant Disease // Radiology. 1940. № 3. P. 322–327.
Stone R.S., Larkin J.C. The treatment of cancer with fast neutrons // Radiology. 1942. № 5. P. 608–620.
Catterall M. First randomized clinical trial of fast neutrons compared with photons in advanced carcinoma of the head and neck // Clin. Otolaryngol. Allied Sci. 1977. V. 2. P. 359–372.
Parker R.G., Berry H.C., Gerdes A.J. et al. Fast neutron beam radiotherapy of glioblastoma multiforme // Am. J. Roentgenol. 1976. № 2. P. 331–335.
Kaul R., Hendrickson F., Cohen L. et al. Fast neutrons in the treatment of salivary gland tumors // Int. J. Radiat. Oncol. Biol. Phys. 1981. № 12. P. 1667–1671.
Cohen L., Hendrickson F., Mansell J. et al. Response of sarcomas of bone and of soft tissue to neutron beam therapy // Int. J. Radiat. Oncol. Biol. Phys. 1984. V. 10. P. 821–824.
Tsunemoto H., Arai T., Morita S. et al. Japanese experience with clinical trials of fast neutrons // Int. J. Radiat. Oncol. Biol. Phys. 1982. № 12. P. 2169–2172.
Battermann J.J., Mijnheer B.J. The Amsterdam fast neutron therapy project: A final report // Int. J. Radiat. Oncol. Biol. Phys. 1986. № 12. P. 2093–2099.
Lindsley K.L., Cho P., Stelzer K.J. et al. Clinical trials of neutron radiotherapy in the United States // Bulletin du Cancer/Radiothérapie. 1996. Sup. 1. P. 78s–86s.
Gribova O.V., Musabaeva L.I., Choynzonov E.L. et al. Neutron therapy for salivary and thyroid gland cancer // AIP Conference Proceedings. 2016. V. 1760. P. 200–210.
Mardynsky Y.S., Sysoyev A.S., Andreyev V.G., Gulidov I.A. Preliminary results of clinical application of reactor fast neutrons in radiation and combined therapy of patients with laryngeal carcinoma // Strahlenther Onkol. 1991. № 3. P. 169–171.
Jones B. Clinical radiobiology of fast neutron therapy: What was learnt? // Front Oncol. 2020. V. 10. 1537.
Gordon K., Gulidov I., Fatkhudinov T. et al. Fast and Furious: Fast Neutron Therapy in Cancer Treatment // International Journal of Particle Therapy. 2022. № 2. P. 59–69.
Gulidov I., Koryakin S., Fatkhudinov T., Gordon K. External Beam Fast Neutron Therapy: Russian Clinical Experience and Prospects for Further Development // Int. J. Radiat. Oncol. Biol. Phys. 2023. № 4. P. 821–827.
Goodhead D.T. Neutrons are forever! Historical perspectives // Int. J. Radiat. Biol. 2019. V. 95. P. 957–984.
Laramore G.E., Griffith J.T., Boespflug M. et al. Fast neutron radiotherapy for sarcomas of soft tissue, bone, and cartilage // Am. J. Clin. Oncol. 1989. V. 12. P. 320–326.
Timoshchuk M.A., Dekker P., Hippe D.S. et al. The efficacy of neutron radiation therapy in treating salivary gland malignancies // Oral Oncol. 2019. V. 88. P. 51–57.
Frey K., Bauer J., Unholtz D. et al. TPS(PET) – A TPS-based approach for in vivo dose verification with PET in proton therapy // Phys. Med. Biol. 2013. № 1. P. 1–21.
Schneider W., Bortfeld T., Schlegel W. Correlation between CT numbers and tissue parameters needed for Monte Carlo simulations of clinical dose distributions // Phys. Med. Biol. 2000. № 2. P. 459–478.
Gordon K.B., Saburov V.O., Koryakin S.N. et al. Calculation of the Biological Efficiency of the Proton Component from 14.8 MeV Neutron Irradiation in Computational Biology with Help of Video Cards // Bulletin of Experimental Biology and Medicine. 2022. V. 173. P. 281–285.
Chernukha A.E., Saburov V.O., Adarova A.I. et al. Three-Dimensional Models and Complimentary Geometry for Dose Evaluation in NG-24MT Based Neutron Radiotherapy Cabinet // Izvestiya vuzov. Yadernaya Energetika. 2022. V. 3. P. 158–167.