GENE  TAG 7 AND ITS TRANSCRIPT TAG7 PROTEIN: PERSPECTIVES OF MEDICAL APPLICATIONS

D. V. Yashin; Яшин Д. В.; L. P. Sashchenko; Сащенко Л. П.; G. P. Georgiev; Георгиев Г. П.

doi:10.31857/S086958732309013X

GENE TAG7 AND ITS TRANSCRIPT TAG7 PROTEIN: PERSPECTIVES OF MEDICAL APPLICATIONS

Authors: Yashin D.V.¹, Sashchenko L.P.¹, Georgiev G.P.¹
Affiliations:
1. Institute of Gene Biology of RAS
Issue: Vol 93, No 9 (2023)
Pages: 824-832
Section: ТЕМАТИЧЕСКИЙ ВЫПУСК ПО БИОЛОГИИ
URL: https://journals.rcsi.science/0869-5873/article/view/229393
DOI: https://doi.org/10.31857/S086958732309013X
EDN: https://elibrary.ru/BBQGDN
ID: 229393

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Abstract
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Abstract

Tag7 protein is a multifunctional protein with antitumor and anti-inflammatory effects. The interaction of Tag7 with the TREM-1 receptor on monocytes leads to the appearance of lymphocytes that kill tumor cells. The Tag7-Hsp70 complex binds to the TNFR1 receptor, causing cell death in a number of tumors through apoptosis and necroptosis. The Tag7-Mts1 complex interacts with the CCR5 receptor and attracts cytotoxic lymphocytes to the tumor. The interaction of Tag7 itself with TNFR1 and TREM-1 receptors prevents the binding of other ligands to this receptor, which gives an anti-inflammatory effect. Peptides imitating different Tag7 activities have been identified in Tag7. The results obtained allow us to count on possible applications of the Tag7 protein in the treatment of oncological and autoimmune diseases.

Keywords

Tag7, Hsp70, Mts1, antitumor activity, anti-inflammatory activity.

References

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