The occurrence of age-related macular degeneration in the presence of a transferred, confirmed COVID-19
- Authors: Frolov M.A.1, Plyaskina U.S.1, Vorobyeva I.V.1,2, Frolov A.M.1, Biryukov V.V.1, Shallakh S.1
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Affiliations:
- Peoples’ Friendship University of Russia named after Patrice Lumumba
- Russian Medical Academy of Continuous Professional Education
- Issue: Vol 29, No 6 (2023)
- Pages: 503-510
- Section: Case reports
- URL: https://journals.rcsi.science/0869-2106/article/view/254737
- DOI: https://doi.org/10.17816/medjrf562780
- ID: 254737
Cite item
Abstract
BACKGROUND: COVID-19 can affect the eyes and both the anterior and posterior segments of the eye. Retinal complications associated with COVID-19 have been reported.
CLINICAL CASE DESCRIPTION: We present a clinical case of age-related macular degeneration that developed during the acute period of coronavirus infection. A patient with COVID-19 and pneumonia (CT-1) experienced sudden decrease in visual acuity within 1 month. A dark spot appeared in front of the left eye, which did not disappear despite eye movements, and distortion of objects was observed. The disease was manifested acutely. A complete ophthalmological examination revealed a sharp decrease in visual acuity and a positive Amsler test (distortion of lines at a distance of 30 cm). In the field of view, scotomas were noted in the center. Ophthalmoscopy revealed light and dark foci in the central macular zone of the retina. Cptical coherence tomography with an angiographic mode detected severe changes at the level of the neuroepithelium and retinal pigment epithelium with the formation of gray tissue. Aflibercept (approved for use in the Russian Federation, No. LP-003544) was intravitreally prescribed according to the clinical guidelines for treating age-related macular degeneration. After treatment with positive dynamics, visual acuity increased to 1.0, and the thickness of the retina decreased by 102 microns.
CONCLUSION: The key objective in making a correct diagnosis was the use of optical coherence tomography with an angiographic mode. This method allows the visualization of the retinal layers without invasion The angiography mode allows the assessment of the state of the foveolar avascular zone and the density and perfusion of blood vessels, which enable the diagnosis of age-related macular degeneration and choroidal neovascularization. Timely antiangiogenic treatment, that is, a single intraocular injection, completely restored the visual acuity and visual field and normalized the state of the retina according to objective data of optical coherence tomography with angiography mode.
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##article.viewOnOriginalSite##About the authors
Mikhail A. Frolov
Peoples’ Friendship University of Russia named after Patrice Lumumba
Email: frolovma@rambler.ru
ORCID iD: 0000-0002-9833-6236
SPIN-code: 1697-6960
MD, Dr. Sci. (Med.), professor
Russian Federation, 6 Miklukho-Maklay street, 117198 MoscowUlyana S. Plyaskina
Peoples’ Friendship University of Russia named after Patrice Lumumba
Author for correspondence.
Email: plyaskina.ulyana@yandex.ru
ORCID iD: 0000-0002-9483-1571
SPIN-code: 3004-8545
Russian Federation, 6 Miklukho-Maklay street, 117198 Moscow
Irina V. Vorobyeva
Peoples’ Friendship University of Russia named after Patrice Lumumba; Russian Medical Academy of Continuous Professional Education
Email: irina.docent2000@mail.ru
ORCID iD: 0000-0003-2707-8417
SPIN-code: 1693-3019
MD, Dr. Sci. (Med.), professor
Russian Federation, 6 Miklukho-Maklay street, 117198 Moscow; MoscowAlexander M. Frolov
Peoples’ Friendship University of Russia named after Patrice Lumumba
Email: frolov_sasha@mail.ru
ORCID iD: 0000-0003-0988-1361
SPIN-code: 6338-9946
MD, Cand. Sci. (Med.), associate professor
Russian Federation, 6 Miklukho-Maklay street, 117198 MoscowVladimir V. Biryukov
Peoples’ Friendship University of Russia named after Patrice Lumumba
Email: vladusmirgerb@gmail.com
ORCID iD: 0000-0002-4130-6511
SPIN-code: 4523-5303
Russian Federation, 6 Miklukho-Maklay street, 117198 Moscow
Sami Shallakh
Peoples’ Friendship University of Russia named after Patrice Lumumba
Email: samishallah@hotmail.com
ORCID iD: 0000-0003-3576-293X
SPIN-code: 5213-1262
Russian Federation, 6 Miklukho-Maklay street, 117198 Moscow
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