Email this article Oxidative stress and inflammation in COVID-19 pathogenesis
- Authors: Kukes V.G.1,2, Parfenova O.K.2, Sidorov N.G.2,3, Olefir Y.V.1, Gazdanova A.А.2
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Affiliations:
- Scientific Centre for Expert Evaluation of Medicinal Products
- I.M. Sechenov First Moscow State Medical University (Sechenov University)
- I.I. Mechnikov Research Institute of vaccines and serums
- Issue: Vol 26, No 4 (2020)
- Pages: 244–247
- Section: Reviews
- URL: https://journals.rcsi.science/0869-2106/article/view/46603
- DOI: https://doi.org/10.17816/0869-2106-2020-26-4-244-247
- ID: 46603
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Abstract
This study discusses the role of oxidative stress and inflammation in the development of severe acute respiratory syndrome (SARS) associated with COVID-19 caused by the novel SARS-CoV-2 coronavirus. An analysis of the literature revealed that the development of respiratory viral infections, including COVID-19, is usually accompanied by the accumulation of acidic metabolic products in the blood and tissues and, accordingly, oxidative stress and increased levels of cytokines. In this regard, it seems appropriate to use the second-generation low-toxic antioxidant Ethoxidol, manufactured in Russia, which reduces the intensity of inflammation, and also improves blood oxygen saturation.
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##article.viewOnOriginalSite##About the authors
Vladimir G. Kukes
Scientific Centre for Expert Evaluation of Medicinal Products; I.M. Sechenov First Moscow State Medical University (Sechenov University)
Author for correspondence.
Email: elmed@yandex.ru
ORCID iD: 0000-0002-5112-6928
doctor of medical sciences, Professor, Academician, Chief Science Officer “Scientific Centre for Expert Evaluation of Medicinal Products”; Professor, Department of Clinical Pharmacology “I.M. First Moscow State Medical University (Sechenov University)”
Russian Federation, MoscowOlga K. Parfenova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Email: oparfenova22@gmail.com
ORCID iD: 0000-0002-0079-2832
Russian Federation, Moscow
Nikita G. Sidorov
I.M. Sechenov First Moscow State Medical University (Sechenov University); I.I. Mechnikov Research Institute of vaccines and serums
Email: deel@yandex.ru
ORCID iD: 0000-0003-1257-8718
Russian Federation, Moscow
Yuri V. Olefir
Scientific Centre for Expert Evaluation of Medicinal Products
Email: olefir@expmed.ru
ORCID iD: 0000-0001-7652-4642
MD, PhD, DSc
Russian Federation, MoscowAlbina А. Gazdanova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Email: gaa71@bk.ru
ORCID iD: 0000-0001-7099-4547
MD, PhD
Russian Federation, MoscowReferences
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