Oxidative stress and inflammation in COVID-19 pathogenesis
- Authors: Kukes V.G.1,2, Parfenova O.K.2, Sidorov N.G.2,3, Olefir Y.V.1, Gazdanova A.А.2
-
Affiliations:
- Scientific Centre for Expert Evaluation of Medicinal Products
- I.M. Sechenov First Moscow State Medical University (Sechenov University)
- I.I. Mechnikov Research Institute of vaccines and serums
- Issue: Vol 26, No 4 (2020)
- Pages: 244–247
- Section: Reviews
- URL: https://journals.rcsi.science/0869-2106/article/view/46603
- DOI: https://doi.org/10.17816/0869-2106-2020-26-4-244-247
- ID: 46603
Cite item
Abstract
This study discusses the role of oxidative stress and inflammation in the development of severe acute respiratory syndrome (SARS) associated with COVID-19 caused by the novel SARS-CoV-2 coronavirus. An analysis of the literature revealed that the development of respiratory viral infections, including COVID-19, is usually accompanied by the accumulation of acidic metabolic products in the blood and tissues and, accordingly, oxidative stress and increased levels of cytokines. In this regard, it seems appropriate to use the second-generation low-toxic antioxidant Ethoxidol, manufactured in Russia, which reduces the intensity of inflammation, and also improves blood oxygen saturation.
Keywords
Full Text
##article.viewOnOriginalSite##About the authors
Vladimir G. Kukes
Scientific Centre for Expert Evaluation of Medicinal Products; I.M. Sechenov First Moscow State Medical University (Sechenov University)
Author for correspondence.
Email: elmed@yandex.ru
ORCID iD: 0000-0002-5112-6928
doctor of medical sciences, Professor, Academician, Chief Science Officer “Scientific Centre for Expert Evaluation of Medicinal Products”; Professor, Department of Clinical Pharmacology “I.M. First Moscow State Medical University (Sechenov University)”
Russian Federation, MoscowOlga K. Parfenova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Email: oparfenova22@gmail.com
ORCID iD: 0000-0002-0079-2832
Russian Federation, Moscow
Nikita G. Sidorov
I.M. Sechenov First Moscow State Medical University (Sechenov University); I.I. Mechnikov Research Institute of vaccines and serums
Email: deel@yandex.ru
ORCID iD: 0000-0003-1257-8718
Russian Federation, Moscow
Yuri V. Olefir
Scientific Centre for Expert Evaluation of Medicinal Products
Email: olefir@expmed.ru
ORCID iD: 0000-0001-7652-4642
MD, PhD, DSc
Russian Federation, MoscowAlbina А. Gazdanova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Email: gaa71@bk.ru
ORCID iD: 0000-0001-7099-4547
MD, PhD
Russian Federation, MoscowReferences
- Delgado-Roche L., Mesta F. Oxidative stress as key player in severe acute respiratory syndrome coronavirus (SARS-CoV) infection. Arch Med Res. 2020;51(5):384-387. doi: 10.1016/j.arcmed.2020.04.019.
- Kolesnikova L.I., Darenskaya M.A., Kolesnikov S.I. Free radical oxidation: a pathophysiologist’s view. Byulleten’ sibirskoy meditsiny. 2017;16(4):16-29. (in Russian) doi: 10.20538/1682-0363-2017-4-16-29.
- Woyke S., Rauch S., Strohle M., Gattere H. Modulation of Hb-O2 affinity to improve hypoxemia in COVID-19 patients. Clin Nutr. 2020; S0261-5614(20)30210-7. doi: 10.1016/j.clnu.2020.04.036.
- Muronets V.I., Fokina K.V., Yazykova M.Yu. Participation of glyceraldehyde-3-phosphate dehydrogenase in the regulation of 2,3-diphosphoglycerate level in erythrocytes. Biokhimiya. 2000;65(4): 547-52. (in Russian)
- Zhao M., Wang M., Zhang J., Ye J., Xu Y., Wang Z. et al. Advances in the relationship between coronavirus infection and cardiovascular diseases. Biomed Pharmacother. 2020;127:110230. doi: 10.1016/j.biopha.2020.110230.
- Divani A.A., Andalib S., Di Napoli M., Lattanzi S., Hussain M.S., Biller J. et al. Coronavirus disease 2019 and stroke: clinical manifestations and pathophysiological insights. J Stroke Cerebrovasc Dis. 2020;29(8):104941. doi: 10.1016/j.jstrokecerebrovasdis.2020.104941.
- Sousa T., Oliveira S., Afonso J., Morato M., Patinha D., Fraga S. et al. Role of H2O2 in hypertension, renin-angiotensin system activation and renal medullary disfunction caused by angiotensin II. Br J Pharmacol. 2012;166(8):2386-401. Doi: 10.1111/j. 1476-5381.2012.01957.x.
- Bloise E., Ciarmela P., Dela Cruz C., Luisi S., Petraglia F., Reis F.M. Activin A in mammalian physiology. Physiol Rev. 2019;99(1):739-80. doi: 10.1152/physrev.00002.2018.
- Hardy C.L., King S.J., Mifsud N.A., Hedger M.P., Phillips D.J., Mackay F. et al. The activin A antagonist follistatin inhibits cystic fibrosis-like lung inflammation and pathology. Immunol Cell Biol. 2015;93(6):567-74. doi: 10.1038/icb.2015.7.
- Hansen J.S., Plomgaard P. Circulating follistatin in relation to energy metabolism. Mol Cell Endocrinol. 2016;433:87-93. doi: 10.1016/j.mce.2016.06.002.
- Kukes V.G., Olefir Y.V., Romanov B.K., Prokofiev A.B., Parfenova E.V., Boldyreva M.A. et al. The mechanism of action of follistatin-like protein-1 (FSTL-1). Vedomosti Nauchnogo tsentra ekspertizy sredstv meditsinskogo primeneniya. 2019;9(4):256-60. (in Russian) doi: 10.30895/1991-2919-2019-9-4-256-260.
- Romanov B.K. Coronavirus disease COVID-2019. Bezopasnost’ i risk farmakoterapii. 2020;8(1):3-8. (in Russian) doi: 10.30895/2312-7821-2020-8-1-3-8.
- Kukes V.G. The results of a study of a domestic drug, an antioxidant of the second generation of ethoxidol. [Itogi issledovaniya otechestvennogo preparata, antioksidanta II pokoleniya etoksidola]. Moscow: MAKFiF; 2017. (in Russian)
- Kukes V.G., Parfenova O.K., Romanov B.K., Prokof’ev A.B., Parfenova E.V., Sidorov N.G. et al. The mechanism of action of ethoxidol on oxidative stress indices in heart failure and hypotension. Sovremennye tekhnologii v meditsine. 2020;12(2):67-73. (in Russian) doi: 10.17691/stm2020.12.2.08.