Evaluation of hematological parameters in inactive hepatitis B infection; neutrophil to lymphocyte ratio and mean platelet volume

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Abstract

AIM: It is estimated that the hepatitis B virus, a serious global public health problem, affects more than 250 million people. Herein, our objective was to quantify several hemogram measurements, like neutrophil-lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), and mean platelet volume (MPV) and to determine their relationship with inflammation in hepatitis B infection (HBV).

MATERIAL AND METHOD: This study included 94 patients aged 2–18 years, who were under follow-up at our hospital for hepatitis B infection between January 1st, 2005 and December 31st, 2015. These individuals served as the patient group. The control group was composed of 88 healthy children of similar age and sex.

RESULTS: There was no significant difference concerning neutrophil count and NLR (p=0.698 and 0.842, respectively). A significantly lower absolute lymphocyte count significantly and a significantly higher MPV was found in the hepatitis B-positive group than in the controls (p <0.05 for both comparisons). The groups had similar hematocrit, hemoglobin, platelet count, RBC count, and white blood cell (WBC) count (p=0.642, p=0.388, p=0.418, p=0.366, and p=0.824, respectively). The two groups individually showed a positive correlation between platelet count and MPV (r=0.32, p=0.01 and r=0.36, p=0.01, respectively). NLR and MPV were positively correlated in both groups (r=0.38, p=0.01 and r=0.41, p=0.01, respectively).

CONCLUSION: In conclusion, the study groups did not exhibit any significant difference concerning NLR, PLR, and PLT/MPV levels but it found a significant intergroup difference in MPV. We believe it is of great importance to develop simpler, inexpensive, and easy-to-use noninvasive methods to determine the level of inflammation in chronic hepatitis B infection; Parameters, such as NLR, PLR, and MPV, can be simple and rapid test markers to serve these purposes.

About the authors

Serhat Samanci

Diyarbakir Children’s Hospital

Email: samanciserhat@hotmail.com
ORCID iD: 0000-0001-9385-132X

MD, Cand. Sci. (Med.)

Turkey, Çocuk Hastalıkları Hastanesi, Dr. Şeref İnalöz, Caddesi No:1, 21100 Yenişehir/ Diyarbakır

Muhammet Kosker

Antalya Training and Research Hospital

Author for correspondence.
Email: muhammetkosker@gmail.com
ORCID iD: 0000-0001-5004-3656

pediatric, infection specialist

Turkey, Antalya

References

  1. Sağlık Bakanlığı TC. [Internet]. Türkiye Viral Hepatit Önleme Ve Kontrol Programi (2018–2023) [cited 2022 Jul 21]. Available from: https://batmanism.saglik.gov.tr/TR,142887/turkiye-viral-hepatit-onleme-ve-kontrol-programi-2018-2023.html. (In Turkish).
  2. Sokal EM, Paganelli M, Wirth S, et al. Management of chronic hepatitis B in childhood: ESPGHAN clinical practice guidelines: consensus of an expert panel on behalf of the European Society of Pediatric Gastroenterology, Hepatology and Nutrition. J Hepatol. 2013;59(4):814–829. doi: 10.1016/j.jhep.2013.05.016
  3. Celikbilek M, Dogan S, Gursoy S, et al. Noninvasive assessment of liver damage in chronic hepatitis B. World J Hepatol. 2013;5(8):439–445. doi: 10.4254/wjh.v5.i8.439
  4. Yilmaz B, Aydin H, Can G, et al. The relationship between fibrosis level and blood neutrophil to lymphocyte ratio in inactive hepatitis B carriers. Eur J Gastroenterol Hepatol. 2014;26(12):1325–1328. doi: 10.1097/MEG.0000000000000204
  5. Liu H, Zhang H, Wan G, et al. Neutrophil-lymphocyte ratio: a novel predictor for short-term prognosis in acute-on-chronic hepatitis B liver failure. J Viral Hepat. 2014;21(7):499–507. doi: 10.1111/jvh.12160
  6. Xiao GQ, Liu C, Liu DL, et al. Neutrophil–lymphocyte ratio predicts the prognosis of patients with hepatocellular carcinoma after liver transplantation. World J Gastroenterol. 2013;19(45):8398–8407. doi: 10.3748/wjg.v19.i45.8398
  7. Hu Y, Lou Y, Chen Y, Mao W. Evaluation of mean platelet volume in patients with hepatitis B virus infection. Int J Clin Exp Med. 2014;7(11):4207–4213.
  8. Ozer S, Yilmaz R, Sonmezgoz E, et al. Simple markers for subclinical inflammation in patients with Familial Mediterranean Fever. Med Sci Monit. 2015;21:298–303. doi: 10.12659/MSM.89228
  9. Kıratlı K.,Çevik E. Investigation of Mean Platelet Volume, Platelet Distribution Width and Erythrocyte Distribution Width in Patients with Hepatitis B Virus Infection. Viral Hepat J. 2017;23(2):60–63. doi: 10.4274/vhd.62534
  10. Hepatitis B fact sheet [Internet]. World Health Organization [cited 2022 Jul 21]. Available from: http://www.who.int/mediacentre/factsheets/fs204/en/.
  11. Karabulut N. Prevalence of HBV, HCV and HIV in inpatients of a Mental Health Hospital in Turkey, 2011–2013. Iran J Public Health. 2015;44(7):1026–1028.
  12. Tong H, Song L, Hoan N, et al. Soluble MICB protein levels and platelet counts during hepatitis B virus infection and response to hepatocellular carcinoma treatment. BMC Infect Dis. 2015;15(1):25. doi: 10.1186/s12879-015-0754-x
  13. Lupberger J, Hildt E. Hepatitis B virus-induced oncogenesis. World J Gastroenterol. 2007;13(1):74–81. doi: 10.3748/wjg.v13.i1.74
  14. Chen L, Lou Y, Chen Y, Yang J. Prognostic value of the neutrophil-to-lymphocyte ratio in patients with acuteon-chronic liver failure. Int J Clin Pract. 2014;68(8):1034–1040. doi: 10.1111/ijcp.12408.
  15. Uluca U, Sen V, Gunes A, et al. İnaktif hepatit B taşıyıcılarında nötrofil lenfosit oranı ve ortalama trombosit hacminin değerlendirilmesi. Mustafa Kemal Üniversitesi Tıp Dergisi. 2015;6(22):8–13. (In Turkish). doi: 10.17944/mkutfd.75063
  16. Atay K. Kronik hepatit B hastalarında ortalama trombosit hacmi, nötrofil/lenfosit oranı ile fibrozis arasındaki ilişki. The Turkish Journal of Academic Gastroenterology. 2019;18(1):7–11. (In Turkish). doi: 10.17941/agd.543387
  17. Noris P, Melazzini F, Balduini CL. New roles for mean platelet volume measurement in the clinical practice? Platelets. 2016;27(7):607–612. doi: 10.1080/09537104.2016.1224828
  18. Henning BF, Zidek W, Linder B, Tepel M. Mean platelet volume and coronary heart disease in hemodialysis patients. Kidney Blood Press Res. 2002;25(2):103–108. doi: 10.1159/000063516
  19. Ekiz F, Yüksel O, Koçak E, et al. Mean platelet volume as a fibrosis marker in patients with chronic hepatitis B. J Clin Lab Anal. 2011;25(3):162–165. doi: 10.1002/jcla.20450
  20. Kaya M.N.,Yıldız A. Correlation Between Liver Fibrozis and MPV in Patients with Chronic Hepatitis B and Chronic Hepatitis C Fırat Tıp Dergisi. Firat Med J. 2021;26(2):83–89.
  21. Atakan-Erkal F, Sepin-Özen N, Emek M, et al. Increased mean platelet volume, red blood cell distribution width and platelet / red blood cell distribution width in patients with Hepatitis B. Turk Hij Den Biyol Derg. 2019;76(1):53–58.
  22. Lindsay BN. The immune system. Essays Biochem. 2016;60(3):275–301. doi: 10.1042/EBC20160017
  23. Zahorec R. Ratio of neutrophil to lymphocyte counts-Rapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl Lek Listy. 2001;102(1):5–14.
  24. Li C, Wen TF, Yan LN, et al. Postoperative neutrophil-to lymphocyte ratio plus platelet-to lymphocyte ratio predicts the outcomes of hepatocellular carcinoma. J Surg Res. 2015;198(1):73–79. doi: 10.1016/j.jss.2015.05.003
  25. Atay K. Relationship between neutrophil-to-lymphocyte ratio, mean platelet volume, and fibrosis level in patients with chronic hepatitis B. Akademik gastroenteroloji dergisi. 2019;18(1):7–11.

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