Cellular proteins as potential targets for antiretroviral therapy
- Authors: Bobkova M.R.1
-
Affiliations:
- I. Mechnikov Research Institute for Vaccines and Sera
- Issue: Vol 68, No 6 (2023)
- Pages: 488-504
- Section: REVIEWS
- URL: https://journals.rcsi.science/0507-4088/article/view/249446
- DOI: https://doi.org/10.36233/0507-4088-207
- EDN: https://elibrary.ru/klgwak
- ID: 249446
Cite item
Abstract
The review article conducts an in-depth analysis of information gleaned from a comprehensive literature search across Scopus, Web of Science, and MedLine databases. The focal point of this search revolves around the identification and exploration of the mechanisms orchestrated by host cell factors in the replication cycle of the human immunodeficiency virus (HIV-1, Retroviridae: Orthoretrovirinae: Lentivirus: Human immunodeficiency virus-1). The article delves into two primary categories of proteins, namely HIV dependence factors (such as CypA, LEDGF, TSG101) and restriction factors (including SERINС5, TRIM5α, APOBEC3G), providing illustrative examples. The current understanding of the functioning mechanisms of these proteins is elucidated, and an evaluation is presented on the potential development of drugs for treating HIV infection. These drugs aim to either inhibit or stimulate the activity of host factors, offering insights into promising avenues for future research and therapeutic advancements.
Keywords
Full Text
##article.viewOnOriginalSite##About the authors
Marina R. Bobkova
I. Mechnikov Research Institute for Vaccines and Sera
Author for correspondence.
Email: mrbobkova@mail.ru
ORCID iD: 0000-0001-5481-8957
Dr. Sci. (Biol.), Chief Researcher of the laboratory of biology of lentiviruses I. Mechnikov Research Institute for Vaccines and Sera, Moscow, Russia
Russian Federation, 105064, MoscowReferences
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