Clinical application of active aspiration fluid biopsy for pancreatic neoplasia diagnosis in oncology practice

A. A. Kashintcev; Кашинцев А. А; N. Yu. Kokhanenko; Коханенко Н. Ю; K. V. Pavelets; Павелец К. В; I. A. Soloviev; Соловьев И. А; D. S. Rusanov; Русанов Д. С; O. G. Vavilova; Вавилова О. Г; Y. V. Radionov; Радионов Ю. В; M. S. Dinikin; Диникин М. С; M. Yu. Agapov; Агапов М. Ю; Y. V. Pelipas; Пелипась Ю. В; Y. A. Gulyaev; Гуляев Ю. А; T. Sh. Morgoshiia; Моргошия Т. Ш; F. A. Magomedova; Магомедова Ф. А; L. A. Solovyova; Соловьева Л. А; A. A. Nadeeva; Надеева А. А; A. V. Borovikova; Боровикова А. В; K. V. Laptev; Лаптев К. В; A. V. Lemeshev; Лемешев А. В; V. Yu. Proutski; Пруцкий В. Ю

doi:10.37469/0507-3758-2025-71-6-OF-2340

Clinical application of active aspiration fluid biopsy for pancreatic neoplasia diagnosis in oncology practice

作者: Kashintcev A.A.¹^,2, Kokhanenko N.Y.¹, Pavelets K.V.¹^,3, Soloviev I.A.³, Rusanov D.S.¹, Vavilova O.G.¹, Radionov Y.V.¹, Dinikin M.S.⁴, Agapov M.Y.⁴, Pelipas Y.V.⁴, Gulyaev Y.A.⁴, Morgoshiia T.S.¹, Magomedova F.A.¹, Solovyova L.A.¹, Nadeeva A.A.², Borovikova A.V.¹^,3, Laptev K.V.³, Lemeshev A.V.¹, Proutski V.Y.²
隶属关系:
1. Saint Petersburg State Pediatric Medical University
2. Pandx LLC
3. SPb SBIH “Mariinskyi hospital”
4. SPb SBIH “City Clinical Oncology Dispensary”
期: 卷 71, 编号 6 (2025)
页面: 1414-1422
栏目: PRACTICES OF ONCOLOGICAL INSTITUTIONS
URL: https://journals.rcsi.science/0507-3758/article/view/380322
DOI: https://doi.org/10.37469/0507-3758-2025-71-6-OF-2340
ID: 380322

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Introduction. Differential diagnosis of pancreatic cystic neoplasms (PCNs) presents a significant clinical challenge due to their structural heterogeneity. Pancreatic juice represents a highly specific biological medium of particular interest, containing both cellular components and potential molecular biomarkers. We present a novel technique — Active Duodenal Aspiration Biopsy (DAB) — enabling collection of pancreatic juice-bile mixtures for diagnostic analysis. Aim. To evaluate the efficacy of this original DAB technique when integrated with standard diagnostic modalities across different levels of oncology care institutions. Materials and Methods. Patients with inconclusive standard diagnostic workups underwent DAB procedures. Aspirates were analyzed cytologically and through carcinoembryonic antigen (CEA) level quantification. Results. In a case series of six patients with various pancreatic cystic neoplasms, DAB demonstrated feasibility and diagnostic utility when combined with conventional verification methods. CEA levels and cytological findings from DAB aspirates enabled precise diagnosis and informed treatment strategy modifications. Conclusion. This preliminary experience indicates DAB is both safe and effective. The technique is applicable across outpatient and inpatient oncology settings and shows potential for improving early pancreatic cancer detection.

关键词

pancreatic cancer, cystic lesion, acute pancreatitis, pancreatic juice

参考

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Заитова Я.О., Кашинцев А.А., Коханенко Н.Ю., et al. Энтеральное питание в лечении острого панкреатита. Медицина: теория и практика. 2023; 8(4): 97-107.-DOI: https://doi.org/10.56871/MTP.2023.41.16.013. [Zaitov Ya.O., Kashintsev A.A., Kokhanenko N.Yu., et al. Enteral feeding in treatment of acute pancreatitis. Medicine: theory and practice. 2023; 8(4): 97-107.-DOI: https://doi.org/10.56871/MTP.2023.41.16.013 (In Rus)].

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Clinical application of active aspiration fluid biopsy for pancreatic neoplasia diagnosis in oncology practice

全文:

详细

关键词

作者简介

A. Kashintcev

N. Kokhanenko

K. Pavelets

I. Soloviev

D. Rusanov

O. Vavilova

Y. Radionov

M. Dinikin

M. Agapov

Y. Pelipas

Y. Gulyaev

T. Morgoshiia

F. Magomedova

L. Solovyova

A. Nadeeva

A. Borovikova

K. Laptev

A. Lemeshev

V. Proutski

参考

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