Peculiarities of the Activity of the Brain Structures of People with Schizophrenia During the Categorization of Objects of Animate and Inanimate Nature

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One of the features of the work of the brain of people suffering from schizophrenia is changes in the activity of their brain during visual categorization of animate and inanimate objects. The purpose of this study was to analyze the brain activity of people with schizophrenia and their visual categorization of objects with different semantic and physical characteristics. It was assumed that the patterns of brain activity in individuals with schizophrenia would differ from the group of healthy individuals both in the early and late stages of visual processing. Using the method of visual evoked potentials, we studied the features of brain activity in 25 people suffering from schizophrenia from 1 to 7 years old, when they categorized images of animate and inanimate nature, low and high spatial frequency. It was found that the amplitudes of P170 (N170) in the left and right posterior and central leads, as well as the amplitudes of P300 in the central lead in people with schizophrenia do not differ during categorization of animate and inanimate objects, which does not correspond to the data obtained earlier from the people without mental health abnormalities. The revealed result is important for a better understanding of the restructuring of the brain during visual perception of objects of different categories, which occurs during the development of schizophrenia.

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作者简介

O. Shchemeleva

Pavlov Institute of Physiology, Russian Academy of Sciences

Email: psy.journ@yandex.ru

Researcher, Laboratory of Physiology of Vision

俄罗斯联邦, St. Petersburg

S. Murav'eva

Pavlov Institute of Physiology, Russian Academy of Sciences

Email: psy.journ@yandex.ru

Researcher, Laboratory of Physiology of Vision

俄罗斯联邦, St. Petersburg

V. Lebedev

Pavlov Institute of Physiology, Russian Academy of Sciences

Email: psy.journ@yandex.ru

Graduate Student, Laboratory of Physiology of Vision

俄罗斯联邦, St. Petersburg

E. Vershinina

Pavlov Institute of Physiology, Russian Academy of Sciences

编辑信件的主要联系方式.
Email: psy.journ@yandex.ru

Senior researcher, laboratory of information technologies and mathematical simulation

俄罗斯联邦, St. Petersburg

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2. Fig. 1. An example of a black-and-white image - an inanimate object subjected to digital filtering by convolution with a DoG function in the region of high (a) and low spatial frequencies (b).

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3. Fig. 2. Averaged evoked potentials recorded in people with schizophrenia in the central lead (Cz), in the occipital-temporal lead on the left (T5) and on the right (T6) when categorizing images of objects of living (black line) and inanimate (gray line) nature, filtered for low (A) and high spatial frequencies (B). Asterisks show significant differences depending on the level of significance when comparing the ratio of the amplitudes of one component within each group at low and high spatial frequencies. Significance level: * — p < 0.05; ** — p < 0.01

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