Mixed-ligand complex [Cu4(bpy)4(PO4)2(CO3)(H2O)2]: synthesis, crystal structure and biological properties

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Abstract

The interaction in the system {Сu(OAc)2·H2O–phytic acid–2,2`-bipyridine (bpy)} in an aqueous-methanol solution led to the formation of a molecular mixed-ligand tetranuclear complex [(Cu4(bpy)4(PO4)2(CO3 )(H2O)2]13H2O (I), the structure of which was established based on the results of an X-ray diffraction experiment (CCDC 2262998). According to X-ray diffraction data, the molecule contains four nonequivalent Cu2+ cations, which coordinate two phosphate anions (PO43-, remaining as a result transformation of the phytate cycle), four neutral bpy, two water molecules and one carbonate anion fragment (CO32-). The presence of a large number of solvate water molecules in the outer coordination sphere created a hydrogen-bonded framework involved in the stabilization of the crystal packing. Study of antimycobacterial activity of I in against the non-pathogenic strain Mycolicibacterium smegmatis showed its high bioeffectiveness.

About the authors

K. A. Koshenskova

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow, Russia

Email: irinalu05@rambler.ru
Россия, Москва

N. V. Makarenko

Institute of Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Vladivostok, Russia

Email: makarenko@ich.dvo.ru
Россия, Владивосток

D. E. Baravikov

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow, Russia; Mendeleev University of Chemical Technology of Russia, Moscow, Russia

Email: irinalu05@rambler.ru
Россия, Москва; Россия, Москва

F. M. Dolgushin

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow, Russia

Email: fmdolgushin@gmail.com
Россия, Москва

O. B. Bekker

Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia

Email: irinalu05@rambler.ru
Россия, Москва

I. L. Eremenko

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow, Russia; Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow, Russia

Email: irinalu05@rambler.ru
Россия, Москва; Россия, Москва

I. A. Lutsenko

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow, Russia

Author for correspondence.
Email: irinalu05@rambler.ru
Россия, Москва

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