A Route to Synthesize Ionizable Lipid ALC-0315, a Key Component of the Lipid Matrix of an mRNA Vaccine
- Autores: Boldyrev I.1, Shendrikov V.1,2, Vostrova A.1, Vodovozova E.1
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Afiliações:
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Mendeleev University of Chemical Technology of Russia
- Edição: Volume 49, Nº 2 (2023)
- Páginas: 216-220
- Seção: ПИСЬМА РЕДАКТОРУ
- URL: https://journals.rcsi.science/0132-3423/article/view/145880
- DOI: https://doi.org/10.31857/S0132342323020069
- EDN: https://elibrary.ru/GHQWWK
- ID: 145880
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Resumo
Ionizable lipid ALC-0315 – ((4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate) – is a part of the lipid matrix of the mRNA vaccine for the prevention of infection with the SARS-CoV-2 virus manufactured by Pfizer/BioNTech. This lipid provides effective assembly of the vaccine particle, protection of mRNA from premature degradation, and after endocytosis, promotes the release of nucleic acid into the cytoplasm for further processing. In this paper, a simplified and economical method for producing ALC-0315 is proposed, which can be used in the production of mRNA vaccines.
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Sobre autores
I. Boldyrev
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: elvod@lipids.ibch.ru
Russia, 117997, Moscow, ul. Miklukho-Maklaya 16/10
V. Shendrikov
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences; Mendeleev University of Chemical Technology of Russia
Email: elvod@lipids.ibch.ru
Russia, 117997, Moscow, ul. Miklukho-Maklaya 16/10; Russia, 125047, Moscow, Miusskaya pl. 9
A. Vostrova
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: elvod@lipids.ibch.ru
Russia, 117997, Moscow, ul. Miklukho-Maklaya 16/10
E. Vodovozova
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Autor responsável pela correspondência
Email: elvod@lipids.ibch.ru
Russia, 117997, Moscow, ul. Miklukho-Maklaya 16/10
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