A Route to Synthesize Ionizable Lipid ALC-0315, a Key Component of the Lipid Matrix of an mRNA Vaccine

I. A. Boldyrev; Болдырев И. А.; V. P. Shendrikov; Шендриков В. П.; A. G. Vostrova; Вострова А. Г.; E. L. Vodovozova; Водовозова Е. Л.

doi:10.31857/S0132342323020069

A Route to Synthesize Ionizable Lipid ALC-0315, a Key Component of the Lipid Matrix of an mRNA Vaccine

Авторлар: Boldyrev I.¹, Shendrikov V.¹^,2, Vostrova A.¹, Vodovozova E.¹
Мекемелер:
1. Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
2. Mendeleev University of Chemical Technology of Russia
Шығарылым: Том 49, № 2 (2023)
Беттер: 216-220
Бөлім: ПИСЬМА РЕДАКТОРУ
URL: https://journals.rcsi.science/0132-3423/article/view/145880
DOI: https://doi.org/10.31857/S0132342323020069
EDN: https://elibrary.ru/GHQWWK
ID: 145880

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Аннотация

Ionizable lipid ALC-0315 – ((4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate) – is a part of the lipid matrix of the mRNA vaccine for the prevention of infection with the SARS-CoV-2 virus manufactured by Pfizer/BioNTech. This lipid provides effective assembly of the vaccine particle, protection of mRNA from premature degradation, and after endocytosis, promotes the release of nucleic acid into the cytoplasm for further processing. In this paper, a simplified and economical method for producing ALC-0315 is proposed, which can be used in the production of mRNA vaccines.

Негізгі сөздер

ionizable lipid, ALC-0315, synthesis, lipid nanoparticles, mRNA

Әдебиет тізімі

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