The Effect of Systemic Endotoxinemia on the Structure of the Brachiocephal Arteries Wall or a Potential Clinical Model for Assessing the Efficacy of Anti-Aging Measures

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Abstract

Integrated indicators of systemic endotoxemia (SEE): the level of endotoxin (ET) and the concentration of antibodies to the hydrophobic (AT-LPS-FOB) and hydrophilic (AT-LPS-PIL) forms of the lipopolysaccharide (LPS) molecule in the general circulation can be used to determine the risk category of atherosclerosis development and progression, which dynamics is an objective marker of aging rate. The comparison of images the structure of brachycephalic arteries wall in dynamics with changes in blood parameters is one of the most successful models for monitoring the atherosclerotic process in a clinical setting. 42 people were examined without the presence of recognized risk factors for the progression of atherosclerosis at baseline and after 1.5-2 years. It was found that lipid profile indicators, such as the concentration of total cholesterol, low and high density lipoproteins, triglycerides, atherogenic index had no prognostic value. Whereas in the group with the progression of damage to the arterial wall, an increase in the concentration of ET was noted with a decrease in the concentration of AT-LPS-FOB and AT-LPS-PIL. In the group with regression of atherosclerotic changes, on the contrary, against the background of a decrease in the concentration of ET, an increase in AT was noted. A prospective study revealed an extremely important fact of a decrease in the concentration of LPS in the blood of patients with positive dynamics of morphological manifestations of atherosclerosis, indicating both the reversibility of the atherosclerotic process and the participation of ET in atherogenesis, which is a real way for extending the life of an individual and indicates the direction to achieve this goal – “antiendotoxin therapy”.

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About the authors

D. P. Pokusaeva

Institute of General Pathology and Pathophysiology

Author for correspondence.
Email: pokusaeva.d@yandex.ru
Russian Federation, Moscow

I. A. Anikhovskaya

Institute of General Pathology and Pathophysiology

Email: pokusaeva.d@yandex.ru
Russian Federation, Moscow

S. G. Morozov

Institute of General Pathology and Pathophysiology

Email: pokusaeva.d@yandex.ru
Russian Federation, Moscow

M. Yu. Yakovlev

Institute of General Pathology and Pathophysiology

Email: yakovlev-lps@yandex.ru
Russian Federation, Moscow

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Supplementary files

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1. JATS XML
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2. Fig. 1. The method of duplex scanning of the extracranial brachiocephalic arteries. 1. Ultrasonic sensor. 2. Carotid artery.

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3. Fig. 2. Method for determining the degree of stenosis ECST = 100 × (S — A)/Sec. A, B, C — the designation of the segments.

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4. Fig. 3. Sonograms of the wall state during primary scanning (by groups). 1. The lumen of the vessel. 2. Unchanged wall. 3. Thickening of the intima-media complex. 4. Formed atherosclerotic plaque. A, B, C — designation of patient groups.

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