Tube Formation Potential of BMSCs and USSCs in Response to HIF-1α Overexpression under Hypoxia
- Авторлар: Razban V.1,2, Khajeh S.3, Alaee S.4, Mostafavi-Pour Z.3, Soleimani M.5
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Мекемелер:
- Department of Molecular Medicine, School of Advanced Medical Sciences and Technologies
- Stem Cell Technology Research Center
- Department of Biochemistry, School of Medicine
- Department of Reproductive Biology, School of Advanced Medical Sciences and Technologies
- Department of Hematology, Faculty of Medicine
- Шығарылым: Том 52, № 3 (2018)
- Беттер: 236-244
- Бөлім: Article
- URL: https://journals.rcsi.science/0095-4527/article/view/173929
- DOI: https://doi.org/10.3103/S0095452718030064
- ID: 173929
Дәйексөз келтіру
Аннотация
Despite numerous studies on therapeutic effects of mesenchymal stem cells on ischemic tissue regeneration, including angiogenesis, their mechanism of action remains ambiguous. Due to the scarce of investigations based on different stem cell sources with known inherent molecular differences, present study compare tube formation of Bone marrow Mesenchymal Stem Cells and Unrestricted Somatic Stem Cells with known reported different Hox gene expression profile in response to HIF-1α overexpression under hypoxia. This might shed light on some parameters for selection of more responsive source with improved therapeutic effects. Superior in vitro tube formation on Matrigel substratum has been observed by Unrestricted Somatic Stem Cells compared to Bone marrow Mesenchymal Stem Cells which might possibly be due to the discriminating molecular properties of stem cell sources. It may help choosing the appropriate stem cell type for a given therapeutic expectations and also suggests some potential targets for future genetic modification of stem cells.
Негізгі сөздер
Авторлар туралы
V. Razban
Department of Molecular Medicine, School of Advanced Medical Sciences and Technologies; Stem Cell Technology Research Center
Хат алмасуға жауапты Автор.
Email: razban_vahid@yahoo.com
Иран, Shiraz; Shiraz
S. Khajeh
Department of Biochemistry, School of Medicine
Email: razban_vahid@yahoo.com
Иран, Shiraz
S. Alaee
Department of Reproductive Biology, School of Advanced Medical Sciences and Technologies
Email: razban_vahid@yahoo.com
Иран, Shiraz
Z. Mostafavi-Pour
Department of Biochemistry, School of Medicine
Email: razban_vahid@yahoo.com
Иран, Shiraz
M. Soleimani
Department of Hematology, Faculty of Medicine
Email: razban_vahid@yahoo.com
Иран, Tehran