The P268S and M863V Polymorphisms of the NOD2/CARD15 Gene in Crohn’s Disease and Ulcerative Colitis
- Authors: Diler S.B.1, Polat F.2, Yaraş S.3
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Affiliations:
- University of Niğ de Omer Halisdemir, Faculty of Science and Letters, Department of Biotechnology
- University of Kocaeli, Faculty of Education, Department of Mathematics and Sciences Education
- University of Mersin, Faculty of Medicine, Department of Gastroenterology
- Issue: Vol 53, No 5 (2019)
- Pages: 424-429
- Section: Article
- URL: https://journals.rcsi.science/0095-4527/article/view/174149
- DOI: https://doi.org/10.3103/S0095452719050074
- ID: 174149
Cite item
Abstract
We aimed to determine P268S and M863V polymorphisms in NOD2/CARD15 genes associated with an increased risk of developing Crohn’s disease (CD) and ulcerative colitis (UC) and to establish correlations between P268S and M863V genotypes in Turkish population. This study included 152 healthy controls and 138 patients (62 CD and 76 UC) with IBD. Our results, the P268S CC genotype was prevalent on patients and controls (45 vs. 66%), followed by genotypes CT (48 vs. 28%) and TT (7 vs. 6%) in CD. The prevalence of genotypes of CC (wild-type), CT (heterozygous mutant) and TT (homozygous mutant) profiles for the P268S polymorphism were 68, 25 and 7% respectively in UC patients, and 66, 28 and 6% respectively in healthy control groups. We were found in wild-type M863V in all subjects and no other mutant band. P268S polymorphism may be associated with CD susceptibility in Turkish population, whereas there is not associated between M863V polymorphisms and patients with IBD in Turkish population.
About the authors
Songül Budak Diler
University of Niğ de Omer Halisdemir, Faculty of Science and Letters, Department of Biotechnology
Author for correspondence.
Email: budakdiler@gmail.com
Turkey, Niğde
Fikriye Polat
University of Kocaeli, Faculty of Education, Department of Mathematics and Sciences Education
Email: budakdiler@gmail.com
Turkey, Kocaeli
Serkan Yaraş
University of Mersin, Faculty of Medicine, Department of Gastroenterology
Email: budakdiler@gmail.com
Turkey, Mersin