Expression Levels of Genes Ptgs2 and Tgfb1 in Esophageal Burns and When Introducing Melanin

Abstract

In this histological study, the degree of esophageal burn was confirmed and the effect of melanin on healing processes, namely, faster periods of recovery of damaged esophageal tissues, was assessed. Higher expression of genes Ptgs2 and Tgfb1 involved in the development of inflammation in blood and esophageal mucosa under conditions of second-degree alkali esophageal burn (AEB 2) was shown. After administration of melanin, the expression levels of genes Ptgs2 and Tgfb1 in blood and esophageal tissues decreased compared to those in the AEB 2 group. It was found that the content of proinflammatory (IL-1β, TNF-α) cytokines in blood and esophageal tissues increased in AEB 2. After administration of melanin, the content of proinflammatory cytokines decreased compared to those of the AEB 2 group. The obtained results demonstrated the anti-inflammatory properties of this compound, showing the prospect of using melanin as a substance contributing to chemical esophageal burn healing.