Synthesis and Pharmacological Activity of Trifluoromethyl-Containing Imidazo[1,2- A ]Benzimidazoles

O. N. Zhukovskaya; A. A. Spasov; T. A. Kuz’menko; A. S. Morkovnik; A. F. Kucheryavenko; V. A. Anisimova; O. A. Salaznikova; K. A. Gaidukova; V. A. Kuznetsova; D. A. Babkov; O. Yu. Grechko; N. V. Eliseeva; A. I. Rashchenko

doi:10.1007/s11094-018-1826-1

Synthesis and Pharmacological Activity of Trifluoromethyl-Containing Imidazo[1,2-A]Benzimidazoles

作者: Zhukovskaya O.¹, Spasov A.²^,3, Kuz’menko T.¹, Morkovnik A.¹, Kucheryavenko A.², Anisimova V.¹, Salaznikova O.², Gaidukova K.², Kuznetsova V.², Babkov D.², Grechko O.², Eliseeva N.², Rashchenko A.²
隶属关系:
1. Institute of Physical and Organic Chemistry, Southern Federal University
2. Volgograd State Medical University
3. Volgograd Medical Scientific Center
期: 卷 52, 编号 5 (2018)
页面: 385-391
栏目: Search for New Drugs
URL: https://journals.rcsi.science/0091-150X/article/view/245203
DOI: https://doi.org/10.1007/s11094-018-1826-1
ID: 245203

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A series of 2-(4-trifluoromethylphenyl)- and 2-trifluoromethyl-9-dialkylaminoalkylimidazo[1,2-a]benzimidazoles were synthesized for the first time by reacting 2-amino-1-dialkylaminoalkylbenzimidazoles and 2-bromo-1-[(4-trifluoromethyl)phenyl]ethanone or 1-bromo-3,3,3-trifluoroacetone and were tested for analgesic and antiplatelet activity, glycogen phosphorylase and dipeptidyl peptidase-4 inhibitory activity, and in vitro glycation of bovine serum albumin.