Synthesis and Pharmacological Activity of Trifluoromethyl-Containing Imidazo[1,2-A]Benzimidazoles
- Authors: Zhukovskaya O.N.1, Spasov A.A.2,3, Kuz’menko T.A.1, Morkovnik A.S.1, Kucheryavenko A.F.2, Anisimova V.A.1, Salaznikova O.A.2, Gaidukova K.A.2, Kuznetsova V.A.2, Babkov D.A.2, Grechko O.Y.2, Eliseeva N.V.2, Rashchenko A.I.2
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Affiliations:
- Institute of Physical and Organic Chemistry, Southern Federal University
- Volgograd State Medical University
- Volgograd Medical Scientific Center
- Issue: Vol 52, No 5 (2018)
- Pages: 385-391
- Section: Search for New Drugs
- URL: https://journals.rcsi.science/0091-150X/article/view/245203
- DOI: https://doi.org/10.1007/s11094-018-1826-1
- ID: 245203
Cite item
Abstract
A series of 2-(4-trifluoromethylphenyl)- and 2-trifluoromethyl-9-dialkylaminoalkylimidazo[1,2-a]benzimidazoles were synthesized for the first time by reacting 2-amino-1-dialkylaminoalkylbenzimidazoles and 2-bromo-1-[(4-trifluoromethyl)phenyl]ethanone or 1-bromo-3,3,3-trifluoroacetone and were tested for analgesic and antiplatelet activity, glycogen phosphorylase and dipeptidyl peptidase-4 inhibitory activity, and in vitro glycation of bovine serum albumin.
About the authors
O. N. Zhukovskaya
Institute of Physical and Organic Chemistry, Southern Federal University
Author for correspondence.
Email: zhukowskaia.ol@yandex.ru
Russian Federation, Rostov-on-Don
A. A. Spasov
Volgograd State Medical University; Volgograd Medical Scientific Center
Email: zhukowskaia.ol@yandex.ru
Russian Federation, Volgograd, 400131; Volgograd, 400131
T. A. Kuz’menko
Institute of Physical and Organic Chemistry, Southern Federal University
Email: zhukowskaia.ol@yandex.ru
Russian Federation, Rostov-on-Don
A. S. Morkovnik
Institute of Physical and Organic Chemistry, Southern Federal University
Email: zhukowskaia.ol@yandex.ru
Russian Federation, Rostov-on-Don
A. F. Kucheryavenko
Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Russian Federation, Volgograd, 400131
V. A. Anisimova
Institute of Physical and Organic Chemistry, Southern Federal University
Email: zhukowskaia.ol@yandex.ru
Russian Federation, Rostov-on-Don
O. A. Salaznikova
Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Russian Federation, Volgograd, 400131
K. A. Gaidukova
Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Russian Federation, Volgograd, 400131
V. A. Kuznetsova
Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Russian Federation, Volgograd, 400131
D. A. Babkov
Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Russian Federation, Volgograd, 400131
O. Yu. Grechko
Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Russian Federation, Volgograd, 400131
N. V. Eliseeva
Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Russian Federation, Volgograd, 400131
A. I. Rashchenko
Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Russian Federation, Volgograd, 400131