Coumarinyl Thiosemicarbazides as Antimicrobial Agents
- 作者: Molnar M.1, Tomić M.2, Pavić V.2
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隶属关系:
- Faculty of Food Technology, Josip Juraj Strossmayer University of Osijek
- Department of Biology, Josip Juraj Strossmayer University of Osijek
- 期: 卷 51, 编号 12 (2018)
- 页面: 1078-1081
- 栏目: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244918
- DOI: https://doi.org/10.1007/s11094-018-1743-3
- ID: 244918
如何引用文章
详细
Two series of coumarinyl thiosemicarbazides were synthesized: one, using the coumarin core substituted in position 7 and another, using same core substituted in position 4. All these compounds were obtained in reactions of the corresponding hydrazide and various isothiocyanates. The structures of all products were confirmed by the 1H and 13C NMR and mass spectrometry techniques. The antimicrobial properties of compounds were tested on four bacterial strains: Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis and Staphylococcus aureus. 2-(2-(7-Hydroxy-2-oxo-2H-chromen-4-yl)acetyl)-N-(2,4,6-trichlorophenyl)hydrazine-1-carbothioamide was found to be the most potent agent against B. subtilis.
作者简介
M. Molnar
Faculty of Food Technology, Josip Juraj Strossmayer University of Osijek
Email: vpavic@biologija.unios.hr
克罗地亚, Osijek
M. Tomić
Department of Biology, Josip Juraj Strossmayer University of Osijek
Email: vpavic@biologija.unios.hr
克罗地亚, Osijek
V. Pavić
Department of Biology, Josip Juraj Strossmayer University of Osijek
编辑信件的主要联系方式.
Email: vpavic@biologija.unios.hr
克罗地亚, Osijek