Coumarinyl Thiosemicarbazides as Antimicrobial Agents

Abstract

Two series of coumarinyl thiosemicarbazides were synthesized: one, using the coumarin core substituted in position 7 and another, using same core substituted in position 4. All these compounds were obtained in reactions of the corresponding hydrazide and various isothiocyanates. The structures of all products were confirmed by the ¹H and ¹³C NMR and mass spectrometry techniques. The antimicrobial properties of compounds were tested on four bacterial strains: Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis and Staphylococcus aureus. 2-(2-(7-Hydroxy-2-oxo-2H-chromen-4-yl)acetyl)-N-(2,4,6-trichlorophenyl)hydrazine-1-carbothioamide was found to be the most potent agent against B. subtilis.