Synthesis and Antimicrobial Properties of Ammonium Salts Containing a Substituted Butyn-2-yl Group

M. O. Manukyan; K. S. Barsegyan; A. Kh. Gyulnazaryan; R. V. Paronikyan; G. M. Stepanyan; N. S. Minasyan; A. V. Babakhanyan

doi:10.1007/s11094-017-1689-x

Synthesis and Antimicrobial Properties of Ammonium Salts Containing a Substituted Butyn-2-yl Group

作者: Manukyan M.¹^,2, Barsegyan K.¹, Gyulnazaryan A.¹, Paronikyan R.³, Stepanyan G.³, Minasyan N.⁴, Babakhanyan A.²
隶属关系:
1. Institute of Organic Chemistry, Scientific-Technical Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
2. Kh. Abovyan Armenian State Pedagogical University
3. A. L. Mndzhoyan Institute of Fine Organic Chemistry, Scientific-Technical Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
4. Center for Molecular Structure Studies, Scientific-Technical Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
期: 卷 51, 编号 9 (2017)
页面: 764-768
栏目: Article
URL: https://journals.rcsi.science/0091-150X/article/view/244793
DOI: https://doi.org/10.1007/s11094-017-1689-x
ID: 244793

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详细

Interaction of 1-dimethylamino-4-diethylaminobutyn-2, 1-dimethylamino-4-piperidinobutyn-2, and 1-dimethylamino-4-morpholinobutyn-2 with the corresponding alkyl esters of monobromo(chloro)acetic acid was used to synthesize novel monoammonium salts. Studies of the antimicrobial activity of the resulting compounds showed that salts containing hydrophobic alkoxycarbonylmethyl radicals had marked antibacterial activity against Gram-positive and Gram-negative microorganisms.

关键词

diamines, ammonium salts, antimicrobial activity, Gram-positive and Gram-negative microorganisms

作者简介

M. Manukyan

Institute of Organic Chemistry, Scientific-Technical Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia; Kh. Abovyan Armenian State Pedagogical University

编辑信件的主要联系方式.
Email: manukyanmeri@gmail.com
亚美尼亚, 26 Azatutyan Prospekt, Erevan, 0014; 17 Tigran Metsi Prospekt, Erevan, 0010

K. Barsegyan

Institute of Organic Chemistry, Scientific-Technical Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia