Synthesis and Antimicrobial Properties of Ammonium Salts Containing a Substituted Butyn-2-yl Group

M. O. Manukyan; K. S. Barsegyan; A. Kh. Gyulnazaryan; R. V. Paronikyan; G. M. Stepanyan; N. S. Minasyan; A. V. Babakhanyan

doi:10.1007/s11094-017-1689-x

Synthesis and Antimicrobial Properties of Ammonium Salts Containing a Substituted Butyn-2-yl Group

Авторы: Manukyan M.¹^,2, Barsegyan K.¹, Gyulnazaryan A.¹, Paronikyan R.³, Stepanyan G.³, Minasyan N.⁴, Babakhanyan A.²
Учреждения:
1. Institute of Organic Chemistry, Scientific-Technical Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
2. Kh. Abovyan Armenian State Pedagogical University
3. A. L. Mndzhoyan Institute of Fine Organic Chemistry, Scientific-Technical Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
4. Center for Molecular Structure Studies, Scientific-Technical Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
Выпуск: Том 51, № 9 (2017)
Страницы: 764-768
Раздел: Article
URL: https://journals.rcsi.science/0091-150X/article/view/244793
DOI: https://doi.org/10.1007/s11094-017-1689-x
ID: 244793

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Аннотация
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Аннотация

Interaction of 1-dimethylamino-4-diethylaminobutyn-2, 1-dimethylamino-4-piperidinobutyn-2, and 1-dimethylamino-4-morpholinobutyn-2 with the corresponding alkyl esters of monobromo(chloro)acetic acid was used to synthesize novel monoammonium salts. Studies of the antimicrobial activity of the resulting compounds showed that salts containing hydrophobic alkoxycarbonylmethyl radicals had marked antibacterial activity against Gram-positive and Gram-negative microorganisms.

Ключевые слова

diamines, ammonium salts, antimicrobial activity, Gram-positive and Gram-negative microorganisms

Об авторах

M. Manukyan

Institute of Organic Chemistry, Scientific-Technical Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia; Kh. Abovyan Armenian State Pedagogical University

Автор, ответственный за переписку.
Email: manukyanmeri@gmail.com
Армения, 26 Azatutyan Prospekt, Erevan, 0014; 17 Tigran Metsi Prospekt, Erevan, 0010

K. Barsegyan

Institute of Organic Chemistry, Scientific-Technical Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia