Quantitative Determination of Mycophenolic Acid in Human Blood Plasma by High-Performance Liquid Chromatography with Tandem Mass-Spectrometric Detection

A. L. Khokhlov; Yu. A. Dzhurko; L. N. Shitov; V. Kubeš; M. Ryska; I. I Yaichkov; A. M. Shitova; V. N. Shabrov; A. E. Miroshnikov

doi:10.1007/s11094-017-1643-y

Quantitative Determination of Mycophenolic Acid in Human Blood Plasma by High-Performance Liquid Chromatography with Tandem Mass-Spectrometric Detection

作者: Khokhlov A.¹^,2, Dzhurko Y.², Shitov L.¹^,2, Kubeš V.², Ryska M.², Yaichkov I.¹^,2, Shitova A.², Shabrov V.², Miroshnikov A.¹
隶属关系:
1. Yaroslavl State Medical University, Ministry of Public Health of the Russian Federation
2. Quinta-Analytica Yaroslavl Co.
期: 卷 51, 编号 6 (2017)
页面: 504-507
栏目: Article
URL: https://journals.rcsi.science/0091-150X/article/view/244678
DOI: https://doi.org/10.1007/s11094-017-1643-y
ID: 244678

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详细

A new rapid and accurate method for determining the mycophenolic acid concentration in human blood plasma using HPLC with tandem mass-spectrometric detection (HPLC-MS/MS) and deproteinization for sample preparation was developed. The method was validated according to the Guideline for Validation of Bioanalytical Methods of EMEA and Guidelines for Examination of Drugs. This method was used to study the pharmacokinetics of mycophenolate sodium.

关键词

mycophenolic acid, deproteinization, HPLC-MS/MS, validation, pharmacokinetics

作者简介

A. Khokhlov

Yaroslavl State Medical University, Ministry of Public Health of the Russian Federation; Quinta-Analytica Yaroslavl Co.

Email: chem@folium.ru
俄罗斯联邦, 5 Revolyutsionnaya St, Yaroslavl, 150000; 52 Leningradskii Prosp, Yaroslavl, 150045