Quantitative Determination of Mycophenolic Acid in Human Blood Plasma by High-Performance Liquid Chromatography with Tandem Mass-Spectrometric Detection

A. L. Khokhlov; Yu. A. Dzhurko; L. N. Shitov; V. Kubeš; M. Ryska; I. I Yaichkov; A. M. Shitova; V. N. Shabrov; A. E. Miroshnikov

doi:10.1007/s11094-017-1643-y

Quantitative Determination of Mycophenolic Acid in Human Blood Plasma by High-Performance Liquid Chromatography with Tandem Mass-Spectrometric Detection

Авторы: Khokhlov A.L.¹^,2, Dzhurko Y.A.², Shitov L.N.¹^,2, Kubeš V.², Ryska M.², Yaichkov I.I¹^,2, Shitova A.M.², Shabrov V.N.², Miroshnikov A.E.¹
Учреждения:
1. Yaroslavl State Medical University, Ministry of Public Health of the Russian Federation
2. Quinta-Analytica Yaroslavl Co.
Выпуск: Том 51, № 6 (2017)
Страницы: 504-507
Раздел: Article
URL: https://journals.rcsi.science/0091-150X/article/view/244678
DOI: https://doi.org/10.1007/s11094-017-1643-y
ID: 244678

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Аннотация

A new rapid and accurate method for determining the mycophenolic acid concentration in human blood plasma using HPLC with tandem mass-spectrometric detection (HPLC-MS/MS) and deproteinization for sample preparation was developed. The method was validated according to the Guideline for Validation of Bioanalytical Methods of EMEA and Guidelines for Examination of Drugs. This method was used to study the pharmacokinetics of mycophenolate sodium.

Ключевые слова

mycophenolic acid, deproteinization, HPLC-MS/MS, validation, pharmacokinetics

Об авторах

A. Khokhlov

Yaroslavl State Medical University, Ministry of Public Health of the Russian Federation; Quinta-Analytica Yaroslavl Co.

Email: chem@folium.ru
Россия, 5 Revolyutsionnaya St, Yaroslavl, 150000; 52 Leningradskii Prosp, Yaroslavl, 150045