电邮这篇文章 Synthesis and Antitumor Properties of New 1,2,4-Triazoles and 1,3,4-Thiadiazoles
- 作者: Ovsepyan T.1, Arsenyan F.1, Nersesyan L.1, Danielyan I.1, Agaronyan A.1, Melik-Ogandzhanyan R.1
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隶属关系:
- A. L. Mndzhoyan Institute of Fine Organic Chemistry, Science and Technology Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
- 期: 卷 50, 编号 11 (2017)
- 页面: 724-727
- 栏目: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244467
- DOI: https://doi.org/10.1007/s11094-017-1520-8
- ID: 244467
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详细
New S-substituted derivatives were synthesized via alkylation of mercapto-substituted 1,2,4-triazoles and 1,3,4-thiadiazoles by various aliphatic and aromatic halides. Aminomethylation of 5-thio-1,2,4-triazoles formed the corresponding Mannich bases. The antitumor properties of the synthesized compounds against sarcoma 37 and EAC grafted tumor models and their influence on DNA methylation were studied
作者简介
T. Ovsepyan
A. L. Mndzhoyan Institute of Fine Organic Chemistry, Science and Technology Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
Email: melik@cornet.am
亚美尼亚, 26 Azatutyan Pr., Yerevan, 0014
F. Arsenyan
A. L. Mndzhoyan Institute of Fine Organic Chemistry, Science and Technology Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
Email: melik@cornet.am
亚美尼亚, 26 Azatutyan Pr., Yerevan, 0014
L. Nersesyan
A. L. Mndzhoyan Institute of Fine Organic Chemistry, Science and Technology Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
Email: melik@cornet.am
亚美尼亚, 26 Azatutyan Pr., Yerevan, 0014
I. Danielyan
A. L. Mndzhoyan Institute of Fine Organic Chemistry, Science and Technology Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
Email: melik@cornet.am
亚美尼亚, 26 Azatutyan Pr., Yerevan, 0014
A. Agaronyan
A. L. Mndzhoyan Institute of Fine Organic Chemistry, Science and Technology Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
Email: melik@cornet.am
亚美尼亚, 26 Azatutyan Pr., Yerevan, 0014
R. Melik-Ogandzhanyan
A. L. Mndzhoyan Institute of Fine Organic Chemistry, Science and Technology Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
编辑信件的主要联系方式.
Email: melik@cornet.am
亚美尼亚, 26 Azatutyan Pr., Yerevan, 0014
