Email this article Synthesis and Antitumor Properties of New 1,2,4-Triazoles and 1,3,4-Thiadiazoles
- Authors: Ovsepyan T.R.1, Arsenyan F.G.1, Nersesyan L.E.1, Danielyan I.S.1, Agaronyan A.G.1, Melik-Ogandzhanyan R.G.1
-
Affiliations:
- A. L. Mndzhoyan Institute of Fine Organic Chemistry, Science and Technology Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
- Issue: Vol 50, No 11 (2017)
- Pages: 724-727
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244467
- DOI: https://doi.org/10.1007/s11094-017-1520-8
- ID: 244467
Cite item
Open Access
Access granted
Subscription Access
Abstract
New S-substituted derivatives were synthesized via alkylation of mercapto-substituted 1,2,4-triazoles and 1,3,4-thiadiazoles by various aliphatic and aromatic halides. Aminomethylation of 5-thio-1,2,4-triazoles formed the corresponding Mannich bases. The antitumor properties of the synthesized compounds against sarcoma 37 and EAC grafted tumor models and their influence on DNA methylation were studied
Keywords
About the authors
T. R. Ovsepyan
A. L. Mndzhoyan Institute of Fine Organic Chemistry, Science and Technology Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
Email: melik@cornet.am
Armenia, 26 Azatutyan Pr., Yerevan, 0014
F. G. Arsenyan
A. L. Mndzhoyan Institute of Fine Organic Chemistry, Science and Technology Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
Email: melik@cornet.am
Armenia, 26 Azatutyan Pr., Yerevan, 0014
L. E. Nersesyan
A. L. Mndzhoyan Institute of Fine Organic Chemistry, Science and Technology Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
Email: melik@cornet.am
Armenia, 26 Azatutyan Pr., Yerevan, 0014
I. S. Danielyan
A. L. Mndzhoyan Institute of Fine Organic Chemistry, Science and Technology Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
Email: melik@cornet.am
Armenia, 26 Azatutyan Pr., Yerevan, 0014
A. G. Agaronyan
A. L. Mndzhoyan Institute of Fine Organic Chemistry, Science and Technology Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
Email: melik@cornet.am
Armenia, 26 Azatutyan Pr., Yerevan, 0014
R. G. Melik-Ogandzhanyan
A. L. Mndzhoyan Institute of Fine Organic Chemistry, Science and Technology Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
Author for correspondence.
Email: melik@cornet.am
Armenia, 26 Azatutyan Pr., Yerevan, 0014
