Issues Related to Patent Protecton of Darunavir and its Analogs
- 作者: Goizman M.1, Zotova O.1, Kamalova A.1, Popova A.1, Shobolov D.1, Korlyukov A.2, Suponitskii K.2, Shimanovskii N.3, Zaitsev S.4, Degterev E.5
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隶属关系:
- Drug Technology Co.
- A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
- N. I. Pirogov State Medical University
- ZAO INFARMA Co.
- Folium Publishing
- 期: 卷 50, 编号 6 (2016)
- 页面: 413-418
- 栏目: Structure of Chemical Compounds, Methods of Analysis and Process Control
- URL: https://journals.rcsi.science/0091-150X/article/view/244407
- DOI: https://doi.org/10.1007/s11094-016-1461-7
- ID: 244407
如何引用文章
详细
It is shown that prolongation of patent protection for the antiviral drug darunavir by patenting it again as darunavir ethanolate is illegal. The claims of the successor patent “Pseudopolymorphic forms of a HIV protease inhibitor,” WO 2003106461 A2, are analyzed and shown to be invalid from both scientific and ethical viewpoints. It is established that darunavir was initially used as its ethanolate. Darunavir is one of the best protease inhibitors of both types of HIV. Currently, not only darunavir ethanolate but also amorphous darunavir (unsolvated) are used as active pharmaceutical ingredients with INN darunavir. This was confirmed by x-ray diffraction studies. Justification for the orderly invalidation of this patent in the RF was given.
作者简介
M. Goizman
Drug Technology Co.
编辑信件的主要联系方式.
Email: goizmanmi@gmail.com
俄罗斯联邦, 2a Rabochaya St., Khimki, Moscow Oblast, 141400
O. Zotova
Drug Technology Co.
Email: goizmanmi@gmail.com
俄罗斯联邦, 2a Rabochaya St., Khimki, Moscow Oblast, 141400
A. Kamalova
Drug Technology Co.
Email: goizmanmi@gmail.com
俄罗斯联邦, 2a Rabochaya St., Khimki, Moscow Oblast, 141400
A. Popova
Drug Technology Co.
Email: goizmanmi@gmail.com
俄罗斯联邦, 2a Rabochaya St., Khimki, Moscow Oblast, 141400
D. Shobolov
Drug Technology Co.
Email: goizmanmi@gmail.com
俄罗斯联邦, 2a Rabochaya St., Khimki, Moscow Oblast, 141400
A. Korlyukov
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
Email: goizmanmi@gmail.com
俄罗斯联邦, Moscow, 28 Vavilova St., 119334
K. Suponitskii
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
Email: goizmanmi@gmail.com
俄罗斯联邦, Moscow, 28 Vavilova St., 119334
N. Shimanovskii
N. I. Pirogov State Medical University
Email: goizmanmi@gmail.com
俄罗斯联邦, 1 Ostrovityanova St., Moscow, 117997
S. Zaitsev
ZAO INFARMA Co.
Email: goizmanmi@gmail.com
俄罗斯联邦, 79/4 Elizarovykh St., Tomsk, 834021
E. Degterev
Folium Publishing
Email: goizmanmi@gmail.com
俄罗斯联邦, Moscow, 127411