Issues Related to Patent Protecton of Darunavir and its Analogs
- Authors: Goizman M.S.1, Zotova O.A.1, Kamalova A.A.1, Popova A.O.1, Shobolov D.L.1, Korlyukov A.A.2, Suponitskii K.Y.2, Shimanovskii N.L.3, Zaitsev S.A.4, Degterev E.V.5
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Affiliations:
- Drug Technology Co.
- A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
- N. I. Pirogov State Medical University
- ZAO INFARMA Co.
- Folium Publishing
- Issue: Vol 50, No 6 (2016)
- Pages: 413-418
- Section: Structure of Chemical Compounds, Methods of Analysis and Process Control
- URL: https://journals.rcsi.science/0091-150X/article/view/244407
- DOI: https://doi.org/10.1007/s11094-016-1461-7
- ID: 244407
Cite item
Abstract
It is shown that prolongation of patent protection for the antiviral drug darunavir by patenting it again as darunavir ethanolate is illegal. The claims of the successor patent “Pseudopolymorphic forms of a HIV protease inhibitor,” WO 2003106461 A2, are analyzed and shown to be invalid from both scientific and ethical viewpoints. It is established that darunavir was initially used as its ethanolate. Darunavir is one of the best protease inhibitors of both types of HIV. Currently, not only darunavir ethanolate but also amorphous darunavir (unsolvated) are used as active pharmaceutical ingredients with INN darunavir. This was confirmed by x-ray diffraction studies. Justification for the orderly invalidation of this patent in the RF was given.
About the authors
M. S. Goizman
Drug Technology Co.
Author for correspondence.
Email: goizmanmi@gmail.com
Russian Federation, 2a Rabochaya St., Khimki, Moscow Oblast, 141400
O. A. Zotova
Drug Technology Co.
Email: goizmanmi@gmail.com
Russian Federation, 2a Rabochaya St., Khimki, Moscow Oblast, 141400
A. A. Kamalova
Drug Technology Co.
Email: goizmanmi@gmail.com
Russian Federation, 2a Rabochaya St., Khimki, Moscow Oblast, 141400
A. O. Popova
Drug Technology Co.
Email: goizmanmi@gmail.com
Russian Federation, 2a Rabochaya St., Khimki, Moscow Oblast, 141400
D. L. Shobolov
Drug Technology Co.
Email: goizmanmi@gmail.com
Russian Federation, 2a Rabochaya St., Khimki, Moscow Oblast, 141400
A. A. Korlyukov
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
Email: goizmanmi@gmail.com
Russian Federation, Moscow, 28 Vavilova St., 119334
K. Yu. Suponitskii
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
Email: goizmanmi@gmail.com
Russian Federation, Moscow, 28 Vavilova St., 119334
N. L. Shimanovskii
N. I. Pirogov State Medical University
Email: goizmanmi@gmail.com
Russian Federation, 1 Ostrovityanova St., Moscow, 117997
S. A. Zaitsev
ZAO INFARMA Co.
Email: goizmanmi@gmail.com
Russian Federation, 79/4 Elizarovykh St., Tomsk, 834021
E. V. Degterev
Folium Publishing
Email: goizmanmi@gmail.com
Russian Federation, Moscow, 127411