Synthesis, Structure, and Analgesic Properties of Phosphorylated Dihydro-1,4-Benzodiazepin-2-Ones*


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详细

Condensation of 3-hydroxy-5-aryl-1.2-dihydro-3H-1.4-benzodiazepin-2-ones with diphenylchlorophosphine was found to produce 3- or 5-diphenylphosphine oxides with high analgesic activity; ED50 values were (0.08 ± 0.02) – (0.97 ± 0.27) mg/kg.

作者简介

V. Pavlovskii

A. V. Bogatskii Physicochemical Institute, Ukrainian National Academy of Sciences

编辑信件的主要联系方式.
Email: medchem_department@ukr.net
乌克兰, 86 Lyustdorfskaya Road, Odessa, 65080

Yu. Gololobov

A. N. Nesmeyanov Institute of Elementary Organic Compounds, Russian Academy of Sciences

Email: medchem_department@ukr.net
俄罗斯联邦, 28 Vavilov Street, Moscow, 119991

S. Andronati

A. V. Bogatskii Physicochemical Institute, Ukrainian National Academy of Sciences

Email: medchem_department@ukr.net
乌克兰, 86 Lyustdorfskaya Road, Odessa, 65080

E. Voronenko

A. V. Bogatskii Physicochemical Institute, Ukrainian National Academy of Sciences

Email: medchem_department@ukr.net
乌克兰, 86 Lyustdorfskaya Road, Odessa, 65080

T. Kabanova

A. V. Bogatskii Physicochemical Institute, Ukrainian National Academy of Sciences

Email: medchem_department@ukr.net
乌克兰, 86 Lyustdorfskaya Road, Odessa, 65080

E. Khalimova

A. V. Bogatskii Physicochemical Institute, Ukrainian National Academy of Sciences

Email: medchem_department@ukr.net
乌克兰, 86 Lyustdorfskaya Road, Odessa, 65080

I. Krasnova

A. N. Nesmeyanov Institute of Elementary Organic Compounds, Russian Academy of Sciences

Email: medchem_department@ukr.net
俄罗斯联邦, 28 Vavilov Street, Moscow, 119991

V. Khrustalev

A. N. Nesmeyanov Institute of Elementary Organic Compounds, Russian Academy of Sciences

Email: medchem_department@ukr.net
俄罗斯联邦, 28 Vavilov Street, Moscow, 119991


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