Enviar artigo por via de e-mail Synthesis, Structure, and Analgesic Properties of Phosphorylated Dihydro-1,4-Benzodiazepin-2-Ones*
- Autores: Pavlovskii V.I.1, Gololobov Y.G.2, Andronati S.A.1, Voronenko E.V.1, Kabanova T.A.1, Khalimova E.I.1, Krasnova I.Y.2, Khrustalev V.N.2
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Afiliações:
- A. V. Bogatskii Physicochemical Institute, Ukrainian National Academy of Sciences
- A. N. Nesmeyanov Institute of Elementary Organic Compounds, Russian Academy of Sciences
- Edição: Volume 50, Nº 4 (2016)
- Páginas: 229-233
- Seção: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244349
- DOI: https://doi.org/10.1007/s11094-016-1428-8
- ID: 244349
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Resumo
Condensation of 3-hydroxy-5-aryl-1.2-dihydro-3H-1.4-benzodiazepin-2-ones with diphenylchlorophosphine was found to produce 3- or 5-diphenylphosphine oxides with high analgesic activity; ED50 values were (0.08 ± 0.02) – (0.97 ± 0.27) mg/kg.
Sobre autores
V. Pavlovskii
A. V. Bogatskii Physicochemical Institute, Ukrainian National Academy of Sciences
Autor responsável pela correspondência
Email: medchem_department@ukr.net
Ucrânia, 86 Lyustdorfskaya Road, Odessa, 65080
Yu. Gololobov
A. N. Nesmeyanov Institute of Elementary Organic Compounds, Russian Academy of Sciences
Email: medchem_department@ukr.net
Rússia, 28 Vavilov Street, Moscow, 119991
S. Andronati
A. V. Bogatskii Physicochemical Institute, Ukrainian National Academy of Sciences
Email: medchem_department@ukr.net
Ucrânia, 86 Lyustdorfskaya Road, Odessa, 65080
E. Voronenko
A. V. Bogatskii Physicochemical Institute, Ukrainian National Academy of Sciences
Email: medchem_department@ukr.net
Ucrânia, 86 Lyustdorfskaya Road, Odessa, 65080
T. Kabanova
A. V. Bogatskii Physicochemical Institute, Ukrainian National Academy of Sciences
Email: medchem_department@ukr.net
Ucrânia, 86 Lyustdorfskaya Road, Odessa, 65080
E. Khalimova
A. V. Bogatskii Physicochemical Institute, Ukrainian National Academy of Sciences
Email: medchem_department@ukr.net
Ucrânia, 86 Lyustdorfskaya Road, Odessa, 65080
I. Krasnova
A. N. Nesmeyanov Institute of Elementary Organic Compounds, Russian Academy of Sciences
Email: medchem_department@ukr.net
Rússia, 28 Vavilov Street, Moscow, 119991
V. Khrustalev
A. N. Nesmeyanov Institute of Elementary Organic Compounds, Russian Academy of Sciences
Email: medchem_department@ukr.net
Rússia, 28 Vavilov Street, Moscow, 119991
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