Design, Synthesis and Evaluation of New Azoles as Antifungal Agents: a Molecular Hybridization Approach
- 作者: Iman M.1, Peroomian T.2, Davood A.2, Amini M.3, Sardari S.4, Azerang P.4
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隶属关系:
- Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences
- Department of Medicinal Chemistry, Pharmaceutical Sciences Branch, Islamic Azad University
- Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences
- Department of Bioinformatics and Drug Design, Institute Pasteur
- 期: 卷 49, 编号 10 (2016)
- 页面: 687-693
- 栏目: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244275
- DOI: https://doi.org/10.1007/s11094-016-1354-9
- ID: 244275
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详细
Two benzimidazole derivatives and one nitroimidazole derivative were designed using molecular hybridization approach. The designed compounds were synthesized and their in vitro antifungal activities were tested against Candida albicans and Saccharomyces cerevisiae strains. Based on the antifungal activity data, compound 9 containing 2-methyl-5-nitroimidazole moiety proved to be the most potent compound. It was more active than the reference drugs fluconazole and ketoconazole against S. cerevisiae.
作者简介
Maryam Iman
Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences
Email: chem@folium.ru
伊朗伊斯兰共和国, Tehran
Talin Peroomian
Department of Medicinal Chemistry, Pharmaceutical Sciences Branch, Islamic Azad University
Email: chem@folium.ru
伊朗伊斯兰共和国, Tehran
Asghar Davood
Department of Medicinal Chemistry, Pharmaceutical Sciences Branch, Islamic Azad University
Email: chem@folium.ru
伊朗伊斯兰共和国, Tehran
Mohsen Amini
Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences
Email: chem@folium.ru
伊朗伊斯兰共和国, Tehran
Soroush Sardari
Department of Bioinformatics and Drug Design, Institute Pasteur
Email: chem@folium.ru
伊朗伊斯兰共和国, Tehran
Parisa Azerang
Department of Bioinformatics and Drug Design, Institute Pasteur
Email: chem@folium.ru
伊朗伊斯兰共和国, Tehran