Design, Synthesis and Evaluation of New Azoles as Antifungal Agents: a Molecular Hybridization Approach
- Авторы: Iman M.1, Peroomian T.2, Davood A.2, Amini M.3, Sardari S.4, Azerang P.4
-
Учреждения:
- Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences
- Department of Medicinal Chemistry, Pharmaceutical Sciences Branch, Islamic Azad University
- Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences
- Department of Bioinformatics and Drug Design, Institute Pasteur
- Выпуск: Том 49, № 10 (2016)
- Страницы: 687-693
- Раздел: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244275
- DOI: https://doi.org/10.1007/s11094-016-1354-9
- ID: 244275
Цитировать
Аннотация
Two benzimidazole derivatives and one nitroimidazole derivative were designed using molecular hybridization approach. The designed compounds were synthesized and their in vitro antifungal activities were tested against Candida albicans and Saccharomyces cerevisiae strains. Based on the antifungal activity data, compound 9 containing 2-methyl-5-nitroimidazole moiety proved to be the most potent compound. It was more active than the reference drugs fluconazole and ketoconazole against S. cerevisiae.
Ключевые слова
Об авторах
Maryam Iman
Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences
Email: chem@folium.ru
Иран, Tehran
Talin Peroomian
Department of Medicinal Chemistry, Pharmaceutical Sciences Branch, Islamic Azad University
Email: chem@folium.ru
Иран, Tehran
Asghar Davood
Department of Medicinal Chemistry, Pharmaceutical Sciences Branch, Islamic Azad University
Email: chem@folium.ru
Иран, Tehran
Mohsen Amini
Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences
Email: chem@folium.ru
Иран, Tehran
Soroush Sardari
Department of Bioinformatics and Drug Design, Institute Pasteur
Email: chem@folium.ru
Иран, Tehran
Parisa Azerang
Department of Bioinformatics and Drug Design, Institute Pasteur
Email: chem@folium.ru
Иран, Tehran